Decode Genetics Ehf

Decode Biostructures, Inc.

Alex Burgin

Mark E Gurney

Vincent Premaratna Sandanayaka

Jasbir Singh

Alexander Kiselyov

Timothy J Hagen

Gary E Schiltz

Kathryn Hjerrild

Lansing J Stewart

Munagala Rao

Adalie Motta

John W Walchli

The invention relates to substituted benzothiazoles, benzoxazoles&#x2014;and their counterparts having pyridine and pyrimidine rings replacing the benzene ring&#x2014;that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is 

Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders

Compounds of the formula: are disclosed. The compounds act as phosphodiesterase-4 modulators, and useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions. Other embodiments are also disclosed.

4-(or 5-) substituted catechol derivatives

The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: A particular embodiment is 

Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders

Pieces of software and databases are used to facilitate the design and synthesis of genes. The synthesis techniques allow identification, quantification, transcription, translation, and manipulation of portions of the gene sequence represented as 0's and 1's in a computing system. These pieces of software and databases compile constraint information provided by a user to create synthetic genes to express proteins lacking disordered or variable regions and containing surface mutations that promote solubility and/or crystallization. Regions of the gene sequence that do not form stable structures can be removed and replaced by a short biological linker to improve crystallization of proteins.

Gene synthesis software

Growing community of inventors

Kingston, WA, United States of America

Alex Burgin