Johns Hopkins University

University of Massachusetts

Animal House, Inc.

Alex Bruce MacDonald

Judith A Whittum-Hudson

Elizabeth S Stuart

William Mark Saltzman

Elizabeth Sutton-Stuart

Ling-Ling An

Myron D Whipkey

Ling Ling An

A genus specific chlamydia vaccine is provided which comprises an anti-idiotype antibody capable of producing in an animal an anti-anti-idiotypic antibody which recognizes a glycoplipid exoantigen (GLXA) of chlamydia. The vaccine is produced by producing an idiotypic antibody to GLXA which, in turn, is utilized t produce the anti-idiotypic antibody comprising the vaccine.

Vaccine comprising anti-idiotypic antibody to chlamydia GLXA and process

A method of detecting chlamydia in a extracellular sample is provided which comprises contacting the sample with an idiotypic antibody to GLXA to form an immunocomplex and detecting the immunocomplex.

Method for diagnosing a patient for chlamydia

A genus specific chlamydia oral or injectable vaccine is provided which comprises an anti-idiotype antibody capable of producing in an animal an anti-idiotypic antibody or Fab fragment thereof enclosed in microspheres formed of a pharmacologically acceptable polymer is capable of producing in an animal an anti-anti-idiotypic immune response (serum antibody, secretory antibody or T-cell responsee) which recognizes a glycolipid exoantigen (GLXA) of chlamydia. The oral or injectable vaccine is produced from an idiotypic antibody to GLXA which, in turn, is utilized to produce the anti-idiotypic antibody.

Oral vaccine comprising anti-idiotypic antibody to chlamydia glycolipid

Growing community of inventors

Amherst, MA, United States of America

Alex Bruce MacDonald