Other

La Region Wallonne

Laregion Wallone

Bioxodes Sa

Ucb S.a.

UniversitÉ Libre De Bruxelles

Smithkline Beecham Biologicals S.a.

Ire-celltarg S.a.

Henogen, S.a.

Improbio

Alex Bollen

Edmond Godfroid

Luc Vanhamme

Yves Decrem

Carol Deby

Joel Pincemail

Alfredo Cravador

Gerard Leboulle

Jean Gobert

Ernst Wulfert

Paul Jacobs

Claudine Bruck

Marc Georges Francis Massaer

G&eacute;rard Leboulle

Sophie Houard

Albert Herzog

Marie-Joelle De Vos-Pierreux

Gérard Leboulle

Nicle Moguilevsky

Michel Pourtois

Marie-Joelle De Vos

The invention relates to a new polynucleotide which encodes a polypeptide expressed in the salivary glands of ticks, more particularly thearthropod tick, during the slow-feeding phase of the blood meal have, said polynucleotide and related polypeptide may be used in different constructions and for different applications which are also included in the present invention.

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The invention relates to a new polynucleotide which encodes a polypeptide expressed in the salivary glands of ticks, more particularly thearthropod tick, during the slow-feeding phase of the blood meal have. The polynucleotide and related polypeptide may be used in different constructions and for different applications which are also included in the present invention.

The present invention provides a novel treatment for allergy comprising a recombinant allergen with reduced enzymatic activity, thereby reducing the potential for an allergic response upon contact with a wild-type allergen.

Recombinant allergen with reduced enzymatic activity

The invention relates to new polynucleotides which encode polypeptides expressed in the salivary glands of ticks, more particularly the arthropod tick, during the slow-feeding phase of the blood meal have. Said polynucleotides and related polynucleotides may be used in different constructions and for different applications which are also included in said invention.

Identification and molecular characterization of proteins, expressed in the Ixodes ricinus salivary glands

Human myeloperoxidase produced by culturing prokaryotic or eukaryotic cells transformed by a vector for the expression of human myeloperoxidase in said cells.

Human myeloperoxidase and its therapeutic application

Nucleic acid probes chemically modified at 5'(OH) and/or at 3'(OH) for

A method of preparing biologically active human myeloperoxidase including the steps of preparing a vector for the expression of human myeloperoxidase. The vector includes plasmid pNIV2703. The plasmid includes a HindIII-SnaBI, HindIII-EcoRV or HindIII-HpaI cassette, the cassette including a complete DNA sequence for hMPO as shown in FIG. 1. CHO cells are transformed with the vector. The cells are cultured. The biologically active human myeloperoxidase is recovered.

Nucleic acid probes specific to the spirochete Borrelia burgdorferi

Prophylactic and therapeutic applications of peroxidases

A substantially pure recombinant human myeloperoxidase heme-containing precursor, comprising a glycoprotein of 84 KD with the amino acid sequence coded for by the nucleotide sequence from 145 to 2235 corresponding to codons 49 to 745 in phase after the first methionine codon in FIG. 1 produced by culturing prokaryotic or eukaryotic cells transformed by a vector for the expression of human myeloperoxidase precursor in said cells.

The subject of the present invention is a nucleic acid probe containing a nucleic acid sequence, wherein the said sequence is linked at its 5' end, via a divalent bifunctional chemical 'arm' L, to a 'labeling component' M, M being a synthetic or natural molecule which is directly or indirectly detectable in a non-isotopic manner, according to the formula I: ##STR1## in which J=H or OH

Nucleic acid probe containing a terminal carbamyl linking

The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.

Expression of human proapolipoprotein A-I

The present invention relates to probes of nucleic acids useful for detecting indifferently the various types of human papilloma virus, particularly HPV1a, HPV5, HPV6b, HPV8, HPV11, HPV16, HPV18 and HPV33, especially a probe comprising a labelled sequence of nucleic acids, characterized in that it comprises the oligomer of twelve nucleotides X-A-A-A-A-C-G-A-A-A-G-X, with X=T or U, or its complement by interchanging A and X on the one hand, C and G on the other hand. The present invention also relates to specific probes of nucleic acids for the detection of human papilloma for each of the types HPV1a, HPV5, HPV8, HPV11, HPV16, HPV18 and HPV33, as well as specific probes of sub-groups of the virus HPV16, HPV18, HPV33 or HPV16 and HPV18 only or again HPV5 and HPV8 only.

Nucleic acid probes of human papilloma virus

Growing community of inventors

Itterbeek, Belgium

Alex Bollen