Ucl Business Plc

Ucl Biomedica Plc

Ryboquin Company Limited

University College London

Alethea Bernice Tabor

Stephen Lewis Hart

Helen Claire Hailes

John Bosco Wong

Christopher Hurley

Aristides Tagalakis

Martin Elbs

Mohd Firouz Mohd Mustapa

Mohn Firouz Mohd Mustapa

Michael Pilkington-Miksa

Stephanie Grosse

A lipid comprising a tri-chain cation having a cationic head group and three or more Chydrocarbyl groups for use in non-viral gene delivery systems, for example in the formation of lipopolyplex transfection vectors. Exceptionally good nucleic acid transfection is observed when nucleic acid and targeting peptides are formulated with the lipid of the invention (or lipid formulated with a co-lipid) into a LPD complex.

Lipids and complexes for the delivery of biologically-active material to cells

The invention provides a peptide derivative of formula A-B-C wherein The invention also provides a lipid derivative of general formula (I):(PEG)-Linker-Spacer-Cationic headgroup-carbon skeleton-(hydrophobic chain)wherein: The peptide and lipid derivatives find use in non-viral gene delivery systems.

Materials and complexes for the delivery of biologically-active materials to cells

The invention provides a lipid of general formula (I) or (II): wherein X, Xand Rto Rare as defined herein. Such lipids are used to form complexes with a biologically-active material such as a nucleic acid, peptide or small molecule for delivering the biologically-active material to cells. The complexes may incorporate an integrin-binding peptide and, when the biologically-active material is DNA, thereby constitute a LID complex.

Materials for the delivery of biologically-active material to cells

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London, United Kingdom

Alethea Bernice Tabor