University System of Maryland

Alba Therapeutics Corporation

Other

Chiron Corporation

Alessio Fasano

Myron M Levine

Blake Paterson

James P Nataro

Stefanie N Vogel

Fernando R Noriega

Ruiliang Lu

Anthony T Maurelli

Marcelo B Sztein

Tammara L Watts

Craig A Bloch

Reinaldo E Fern&aacute;ndez

Rino Rappuoli

Julie Brownley

Teresa De Magistris

Karen Lammers

Sergio Uzzau

Peter Ward

Rosangela Mezghanni

Michael K Tanner

The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.

Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress syndrome

The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease.

Materials and methods for the treatment of celiac disease

Disclosed are methods of preparing multi-cellular three-dimensional tissue constructs, that include fibroblasts, endothelial cells, lymphocytes and epithelial cells. The present methods may include embedding fibroblasts and endothelial cells in a matrix enriched with gut basement membrane proteins to form a cell containing matrix that is then added to a bioreactor and exposed to epithelial cells and activated lymphocytes as the cell cultures. Also provided are the tissue constructs formed from such methods, a matrix enriched with gut basement membrane proteins and kits that include the same. Further provided are methods of measuring toxicity of a pathogen or commensal organisms, chemosensitivity of tissues to a toxic material and inflammatory conditions, which use the present multi-cellular three-dimensional tissue constructs.

Multicellular organotypic model of human intestinal mucosa

The present invention provides antibacterial peptides isolated fromGG. Also provided are methods of treating an individual having a bacterial infection or at risk for developing a bacterial infection, comprising the steps of administering an antibacterial peptide of the invention to an individual having a bacterial infection or at risk for developing a bacterial infection.

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A method for preventing or delaying the onset of autoimmune diseases is disclosed.

Pharmaceutical compositions for inhibiting intestinal permeability

Agonist polypeptide of a receptor protein has been identified. The agonist can be used to facilitate drug and antigen absorption. Suitable routes of administration include oral, nasal, transdermal, and intravenous. Pharmaceutical formulations may comprise a therapeutic agent or an immunogenic agent in combination with the agonist polypeptide.

Agonist polypeptide of receptor for ZOT and zonulin

CXCR3 is identified as a physiological receptor for Gliadin. Assays for determining modulators of CXCR3 signaling are provided. Fragments of gliadin which function as inhibitors of CXCR3 signaling can be determined. Methods for treating diseases relating to gluten and/or autoimmunity by targeting CXCR3 are provided. Such diseases include celiac disease, gluten sensitivity, gluten allergy, rheumatoid arthritis, multiple sclerosis, immune-mediated or type 1 diabetes mellitus, inflammatory bowel diseases, systemic lupus erythematosus, psoriasis, scleroderma, and autoimmune thyroid diseases.

Methods for screening for modulators of CXCR3 signaling

Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions.

Method for treating or inhibiting intestinal inflammation

Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes

Pharmaceutical composition and method for inhibiting gastrointestinal inflammation

Agonist polypeptide of receptor for Zot and Zonulin

Peptide antagonists of zonulin and methods for use of the same

A method for prevention of delaying the onset of diabetes using peptide antagonists of zonulin, is disclosed.

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West Friendship, MD, United States of America

Alessio Fasano