Astex Therapeutics Limited

Alessia Millemaggi

Gianni Chessari

Christopher Norbert Johnson

Gordon Saxty

Steven Howard

Thomas Daniel Heightman

Lee William Page

Maria Grazia Carr

Andrew James Woodhead

Gilbert Besong

David Norton

Christopher Charles Frederick Hamlett

Neil Thomas Thompson

Hendrika Maria Gerarda Willems

Steven Douglas Hiscock

Susanne Maria Saalau-Bethell

The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Bicyclic heterocycle compounds and their uses in therapy

The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

The invention provides compounds that are useful in the treatment of hepatitis C virus (HCV) infections. The compounds have the formula (1): or a salt, N-oxide, tautomer or stereoisomer thereof, wherein A is CH or N; E is CH or N;

Pharmaceutical compounds

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Cambridge, United Kingdom

Alessia Millemaggi