Gambro Lundia Ab

Gambro Dasco S.p.a.

Alessandro Surace

Paolo Rovatti

Carlo Alberto Lodi

Jan P Sternby

Kristian Solem

Thomas Hertz

Anders Nilsson

Anders Wallenborg

Francesco Fontanazzi

Francesco Paolini

Francesco Rosati

An extracorporeal blood treatment apparatus is provided comprising a filtration unit connected to a blood circuit and to a dialysate circuit, a preparation device for preparing and regulating the composition of the dialysis fluid; a control unit is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line at a set point based on the physician prescription; starting from the initial patient plasma conductivity, estimated at the beginning of the treatment, and based on the target plasma conductivity/sodium concentration which is equivalent to the dialysate conductivity/sodium concentration prescribed, the control unit determines the minimum constant gradient between dialysis fluid and plasma conductivity/concentration to be maintained during treatment to achieve the conductivity/concentration target in the patient plasma at the end of the session.

Apparatus for extracorporeal blood treatment

An extracorporeal blood treatment apparatus includes a filtration unit () connected to a blood circuit () and a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating of the dialysis fluid up to the calculating of the initial plasma conductivity performed by maintaining the dialysis fluid conductivity substantially constant.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid; a control unit () is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line () at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit () connected to a blood circuit () and to a dialysate circuit (), a preparation device () for preparing and regulating the composition of the dialysis fluid, and a sensor () for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit () configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

A method of operating an extracorporeal blood treatment includes, prior to commencing an extracorporeal blood treatment, reading from a storage device () stored values of a patient-specific prescription parameter. These stored values relate to a sequence of previous extracorporeal blood treatments. In addition, the method includes processing the stored values of the parameter read from the storage device () according to a predetermined algorithm to determine a current value of the patient-specific prescription parameter. The current value is then available for the subsequent extracorporeal blood treatment.

Extracorporeal blood treatment system for individualized treatment

Extracorporeal blood treatment apparatus having dialysis fluid parameter data entry

An apparatus for extracorporeal treatment of blood () comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit () is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. The value of the effectiveness parameter is calculated using one or more values representative of the conductivity in the spent dialysate line obtained relying on a mathematical model.

Apparatus for determining a parameter indicative of the progress of an extracorporeal blood treatment

It is disclosed an apparatus for extracorporeal blood treatment () having a control unit () connected to an ultrafiltration device () and to a fluid preparation section () of fresh dialysis liquid. The control unit () is configured to receive measured values of the change of blood volume, the amount of ultrafiltration volume, and conductivity or to the concentration for at least one substance in the blood (BV %; U, WL; Cb; the control unit () is also configured to receive prescription values for the same parameters and to control ultrafiltration and adjust conductivity in the fresh dialysis liquid based on the difference between said measured values and said prescription values.

An apparatus for extracorporeal blood treatment including a treatment unit; an extracorporeal blood circuit; an infusion line of a replacement fluid; a dialysis line connected in inlet to the second chamber; a fluid evacuation line; sensors for determining a first parameter relating to a patient's blood volume (BV %), a second parameter relating to an ultrafiltration flow rate (UFR) or to a patient's weight loss rate (WLR), a third parameter (Cd, Na) relating to a conductivity or concentration of a liquid crossing the dialysis line and/or the infusion line, and a fourth parameter relating to an infusion flow rate (Q), and a control unit performing a control procedure to determine a variation in blood volume (BV %) and perform a setting sequence, wherein the control unit regulates a transmembrane pressure (TMP) to values which enable maximizing the convective exchanges.

An apparatus for extracorporeal blood treatment is described, including a treatment unit, an extracorporeal blood circuit, an infusion line of a replacement fluid, a dialysis line connected in inlet to the second chamber, and a fluid evacuation line; sensors for determining a first parameter relating to a patient's blood volume (BV %) a second parameter relating to an ultrafiltration flow rate (UFR) or to a patient's weight loss rate (WLR), a third parameter (Cd, Na) relating to a conductivity or concentration of a liquid crossing the dialysis line and/or the infusion line, and a fourth parameter relating to an infusion flow rate (Q), and a control unit for performing a control procedure.

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Carpi, Italy

Alessandro Surace