Eniricerche S.p.a.

Sclavo Spa

Polifarma S.p.a.

A. Menarini Industrie Farmaceutiche Riunite S.r.l.

Enichem S.p.a

Eni-ente Nazionale Idrocarburi

Menarini Ricerche S.p.a.

Malesci Istituto Farmacobiologico S.p.a.

Scalvo Spa

A. Menarini Industrie Farmaceutiche Reiunite S.r.l.

Alessandro Sisto

Antonio S Verdini

Antonino Virdia

Federico Maria Arcamone

Paolo Lombardi

Stefano Manzini

Edoardo Potier

Vincenzo Politi

Giovanna De Luca

Giovanni Di Stazio

Christopher Fincham

Luciano Nencioni

Luigi Villa

Sabina Mariotti

Carlo Alberto Maggi

Danilo Giannotti

Alessandro Giolitti

Valerio Caciagli

Maria Altamura

Valentina Fedi

Antonio Guidi

Nicholas Harmat

Rossano Nannicini

Antonio Virdia

Franco Pasqui

Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I) 

Linear basic compounds having NK-2 antagonist activity and formulations thereof

The present invention refers to tachykinins antagonists of general formula (I) ##STR1## their preparation and pharmaceutical compositions containing them.

Tachykinins antagonists

A description is given of tachykinin receptor antagonists having general formula (I) ##STR1## their preparation and use in pharmaceutical formulations.

Tachykinin antagonists

Tachyquinine antagonists, their preparation and use in pharmaceutical

New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5.sup.1-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described which are of the general formula (I) ##STR1## where R is hydrogen or an acyl radical, and R.sup.1 is an --OR.sup.2 group or an ##STR2## group where R.sup.2 is a hydrogen atom or a hydrocarbon radical, and R.sup.3 is a hydrogen atom or a hydroxyl group, and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.

Retro-inverso analogues of thymopentin and the method for their synthesis

New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts. A process of preparing the tripeptide fragment of formula I is also described. The new compounds are enzyme-resistant immunomodulatory peptides.

Process for preparing new thymopentin retro-inverso analogs and

New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5.sup.1-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described. The new compounds, of general formula (I) ##STR1## where R is hydrogen or an acyl radical, and

Retro-inverso analogues of thymopentin, and their use in the preparation

Tripeptides having hypotensive activity, defined by the following general formula:

Tripeptide compounds having hypotensive activity

New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts. The new compounds are enzyme-resistant immunomodulatory peptides.

New thymopentin retro-inverso analogs and fragments thereof, a process

Pharmacologically active tripeptides, with at least a retro-inverted peptidic bond, definable by means of the following general formulae: ##STR1## their pharmaceutically acceptable salts, esters or alkyl amides, wherein

Pharmacologically active tripeptides and process for their synthesis

Retro-inverted peptides, analogues of Bradykinin Potentiator Pentapeptide (BPP.sub.5a), definable by the general formula (I) ##STR1## useful as antihypertensives and diagnostics.

Retro-inverted peptides analogues of Bradykinin Potentiator BPP.sub.5a

Peptido-mimetic compounds of hypotensive action definable by the general formula: ##STR1## in which: X represents the pyroglutamic acid residue or a ##STR2## residue where R.sub.2 represents a hydrogen atom, an alkyloxycarbonyl, an arylalkyloxycarbonyl or an acyl group with from 1 to 7 carbon atoms in the linear chain,

Peptido-mimetic substances with hypotensive action

New partially retro-inverso peptides of the following general formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent, each independently, the side chain of the aminoacid residues present in the naturally occuring peptides, X is --S--Ph or --O--CH.sub.2 --Ph and Z is a hydroxy, alkoxy or amino group, are described as well as a suitable method for their preparation. The new compounds are useful as antihypertensive agents.

Retro-inverso analogs of the bradykinin potentiating peptide BPP.sub.5a

This invention relates to new retro-inverso peptides and peptide derivatives in the form of analogues of the bradykinin potentiating peptide (BPP.sub.5a), which are pharmacologically active, have long in vivo life and are useful as antihypertensives and diagnostic drugs, their general formula (I) being ##STR1##

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Rome, Italy

Alessandro Sisto