Medivir Ab

Alessandro Schipani

Nils-Gunnar Johansson

Ian Gilbert

Gian Filippo Ruda

Ganasan Kasinathan

Dolores Gonzalez Pacanowska

Corinne Nguyen

Deoxyuridine derivatives of the formula where

Dutpase inhibitors

Deoxyuridine derivatives of the formula (I) where Ris H or various substituents; D is &#x2014;NHCO&#x2014;, &#x2014;CONH&#x2014;, -0-, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;CH&#x2550;CH, &#x2014;C&#x2261;C&#x2014;, &#x2014;NR&#x2014;; Ris hydrogen or various substituents; Ris H, C-Calkyl, C-Calkanoyl; E is Si or C; R, Rand Rare independently selected from C-Calkyl, C-Calkenyl, C-Calkynyl or a stable monocyclic, bicyclic or tricyclic ring system; G is &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;CHR&#x2014;, &#x2014;C(&#x2550;O)&#x2014;; J is &#x2014;CH&#x2014;, or when G is CHRmay also be &#x2014;O&#x2014; or &#x2014;NH&#x2014;; Ris H, F, &#x2014;CH, &#x2014;CHNH, &#x2014;CHOH; &#x2014;OHRis H, F, &#x2014;CH, &#x2014;CHNH, &#x2014;CHOH, &#x2014;CH(OH)CH, CH(NH)CH; or Rand Rtogether define an olefinic bond, or together form a &#x2014;CH-group, thereby defining a cis or trans cyclopropyl group; have utility in the prophylaxis or treatment of protozoal diseases such as malaria. 

DUTPase inhibitors

Deoxyuridine derivatives of Formula (I'); where A is O, S or CH; B is O, S or CHR; Ris H, or various substituents; Ris H, F; Ris H, F, OH, NH; or Rand Rtogether form a chemical bond; D is &#x2014;NHCO&#x2014;, &#x2014;CONH&#x2014;, &#x2014;O&#x2014;, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;CH&#x2550;CH, &#x2014;C&#x2261;C&#x2014;, &#x2014;NR&#x2014;; Ris hydrogen or various substituents; Ris H, C-Calkyl, C-Calkanoyl; E is Si or C; R, Rand Rare independently selected from C-Calkyl, C-Calkenyl, C-Calkynyl, or a stable monocyclic, bicyclic or tricyclic ring system have utility in the prophylaxis of treatment of parasitic diseases such as malaria. 

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Dundee, United Kingdom

Alessandro Schipani