Umc Utrecht Holding B.v.

Alessandro Sbrizzi

Cornelis Antonius Theodorus Van Den Berg

Annette Van Der Toorn

Oscar Van Der Heide

The present patent disclosure describes a new method and a new device for determining a spatial distribution of at least one tissue parameter within a sample based on a time domain magnetic resonance, TDMR, signal emitted from the sample after excitation of the sample according to an applied pulse sequence. The spatial distribution is determined using a calculated sparse Hessian, wherein the sparse Hessian is calculated based on the applied pulse sequence.

Parameter map determination for time domain magnetic resonance

A system for performing time-domain magnetic resonance imaging includes an excitation device for transiently exciting a sample thereby causing the sample to emit an MRI signal. A receiving coil receives the MRI signal. A simulated signal of the receiving coil is generated in a time domain, based on a plurality of spatial parameter distributions, wherein the spatial parameter distributions include a spatial distribution of a magnetization, wherein the spatial parameter distributions further include at least one of a spatial distribution of a material property of a material of the sample and a spatial distribution of an electromagnetic field. An objective function is based on a difference between the received MRI signal and the simulated signal in the time domain. The plurality of spatial parameter distributions are fitted based on the objective function. The sample is excited again before the sample reaches an equilibrium state.

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Utrecht, Netherlands

Alessandro Sbrizzi