Gelesis LLC

Sca Hygiene Products Ab

Other

Ospedale San Raffaele S.r.l.

Caresilk Srls

Universita'del Salento

Ghimas S.p.a.

Ambrosio, Luigi

Sannino, Alessandro

As & Partners S.r.l.

Megatex S.p.a.

Nicolais, Luigi

Alessandro Sannino

Yishai Zohar

Christian Demitri

Eyal S Ron

Barry Joseph Hand

Cosimo Saponaro

Luigi Nicolais

Hassan Heshmati

Luigi Ambrosio

Fabrizio Porro

Maria Rescigno

Giuseppe Mensitieri

Giuseppe Peretti

Vincenzo Maria De Benedictis

Matteo Del Nobile

Fausto Esposito

Guiseppe Mensitieri

Alessandra Silvestri

Federica Paladini

Mauro Pollini

Daniela Rosa Deponti

Cinzia Domeneghini

Alessia Di Giancamillo

Francesco Scalera

Francesca Gervaso

Gianfranco Fraschini

Elaine Chiquette

Antonio Licciulli

Antonio Alessandro Licciulli

Francesca Scalera

Alfonso Maffezzoli

The present invention relates to methods of managing weight, and treating overweight or obesity and treating or preventing diabetes in a subject in need thereof. In one embodiment, the method comprises the steps of (a) orally administering to the subject from about 0.7 g to about 4 g of crosslinked carboxymethylcellulose; and (b) orally administering to the subject at least about 100 mL of water per gram of crosslinked carboxymethylcellulose. Steps (a) and (b) are conducted prior to or with at least one meal per day.

Methods for treating overweight or obesity

The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80&#xb0; C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.

Method for producing hydrogels

The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

Method for producing hydrogels coupling high elastic modulus and absorbance

The present invention relates to new methods for crosslinking a polysaccharide with a bifunctional poly(ethylene glycol). The invention further includes the polymer hydrogels which can be produced using these methods, compositions comprising the polymer hydrogels and methods of use thereof.

Superabsorbent materials and methods of production thereof

A synthetic composite material for tissue repair is disclosed which includes a first layer having an organic material and having side walls and external surface; and a second porous layer comprising an inorganic material and having side walls; wherein the first layer is in direct contact with the second layer and wherein the side walls of the first layer and the side walls of the second layer are coated with a third layer of the organic material.

Composite scaffold for tissue repair

The invention relates to methods of depositing silver onto a substrate using a dilute silver salt solution.

Processes for deposition of elemental silver onto a substrate

Compositions and methods are provided for treating a gut permeability-related disease or disorder comprising administering to the gastrointestinal tract of a subject in need thereof, a therapeutically effective amount of a hydrogel having an elastic modulus (G') of at least about 500 Pa.

Compositions and methods for treating or preventing gut permeability-related disorders

The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.

Method for treating constipation

The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.

Polymer hydrogels and methods of preparation thereof

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Lecce, Italy

Alessandro Sannino