Dipharma Francis S.r.l.

Alessandro Restelli

Gabriele Razzetti

Pietro Allegrini

Giuseppe Barreca

Emanuele Attolino

Chiara Vladiskovic

Enrico Brunoldi

Philipp Carboni

Alessandro De Marco

Alessio Bove

Massimo Magnani

Processes for the synthesis and purification of glycoconjugate derivatives of cholic acid of formula (I) are provided herein.

Synthesis of glycoconjugate derivatives of a bile acid

The present invention relates to a process for the preparation of selegiline base, an irreversible and selective inhibitor of the MAO-B enzymes and which is used in the treatment of Parkinson's Disease.

Method for preparing selegiline base

The present invention relates to a process for the preparation of anhydrous crystalline 2-(R)-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl]-1H-benzimidazole (dexlansoprazole).

Process for the preparation of crystalline dexlansoprazole

The present invention relates to a new process for the isolation and purification of 6-aminocaproic acid, which is a known inhibitor of enzymes responsible for fibrinolysis and is used in the treatment of coagulopathies and severe post-operative bleedings.

Isolation and purification of 6-aminocaproic acid

Process for the preparation of crystalline anhydrous (R)-2-[[[3-methyl-4-(2,2,2-trifluoroetoxy)-2-piridyl]methyl]sulphinyl]benzimidazole (dexlansoprazole).

Rabeprazole sodium in the monohydrate crystalline form, pharmaceutical compositions thereof, the use thereof in therapy, a process for its preparation, and the use thereof for the purification of rabeprazole sodium.

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Baranzate, Italy

Alessandro Restelli