Ethicon Endo-surgery, Inc.

The General Hospital Corporation

Alessandro Pastorelli

Federico Bilotti

Michele D'Arcangelo

Jason L Harris

Mark S Ortiz

William Bruce Weisenburgh, Ii

Mark S Zeiner

Brian James Thompson

Frederick E Shelton, IV

Christopher J Hess

Mark D Overmyer

Michael J Stokes

Jeffrey L Aldridge

Sean P Conlon

James Walden Voegele

Galen C Robertson

Michael S Cropper

Prasanna Malaviya

Daniel F Dlugos, Jr

James A Woodard, Jr

Thomas Edward Albrecht

Jesse J Kuhns

Tamara S Vetro Widenhouse

Laszlo Csiky

Todd Phillip Omaits

Denzel Z Herrera-Davis

Roberto Tacchino

Michele D'arcangelo

David C Yates

Foster B Stulen

Christopher W Widenhouse

Lauren S Weaner

Andrew M Zwolinski

Kevin D Felder

Michael A Murray

Rocco Crivelli

Toralf Bork

Martin Pfleiderer

Yanik Tardy

Mathilde Miguras

Michele D' Arcangelo

Kevin L Houser

Chad Paul Boudreaux

Jeffrey David Messerly

Thomas W Huitema

John V Hunt

Amy L Marcotte

Lee M Kaplan

Mark A Neurohr

Anthony T Nguyen

Antonio Longo

George Mark Pomeroy

Drago Popovic

Tacchino Roberto

Mario Gutierrez

Glenda C Marsh

Nadia N Ahmad

Todd P Omaits

George M Pomeroy

Heather Bowman

William Bruce Weisenburgh Ii

Methods and compositions are provided for treating metabolic disorders by modulating bile acid levels. Generally, the methods and compositions can modulate bile acid levels, such as serum bile acid levels, to treat a metabolic disorder. In one embodiment, a method of modulating a bile acid level includes measuring a bile acid level and delivering a composition effective to modulate the bile acid level. A method for modulating a bile acid profile includes comparing a bile acid profile to a target profile and delivering a bile acid cocktail to increase bile acid levels. In another embodiment, a pharmaceutical composition for increasing bile acid levels includes a bile acid cocktail effective to increase bile acid levels. The composition is further useful as part of an implantable system.

Methods and compositions of bile acids

A surgical stapling instrument () comprises a staple fastening assembly () in the distal region of said instrument, the staple fastening assembly () including a cartridge device () which comprises at least one closed row () of staples and defines a wavy distal end surface (), and an anvil () which defines a wavy proximal staple forming surface () substantially matching the distal end surface () and which is adapted to cooperate with the cartridge device () for forming the ends of the staples exiting from the cartridge device (), wherein the distal end surface () and the staple forming surface () have a globally wavy shape including two opposite peaks () and two opposite valleys () angularly spaced at about 90&#xb0; from the adjacent peaks () and in that said two-peaks-two-valleys wavy shape is formed by a stepped configuration of said surfaces ().

Surgical stapling instrument

A system for stimulating the release of satiety hormone in a subject comprises a stimulus device which is implantable in the subject and adapted to apply an electrical stimulus to a tissue of a gastrointestinal system of said subject, and a detection device which is implantable in the subject and adapted to continuously monitoring at least one of a mechanical characteristic and an electrical characteristic of the subject to detect an ingestion of food by said subject, wherein the detection device cooperates with the stimulus device such that the stimulus device applies said electrical stimulus in response to a detected ingestion of food.

Devices and methods for the treatment of metabolic disorders

A system for stimulating the release of satiety hormone in a subject comprises a stimulus device () having a tissue engaging portion () intended to be placed in contact with a target tissue () of a gastrointestinal system of the subject, a movement device () linked with the tissue engaging portion () and operable to move the tissue engaging portion (), thereby mechanically stimulating the target tissue (), and an anchoring device for permanently fastening the stimulus device () in a target location at the gastrointestinal system such that the tissue engaging portion () engages the target tissue ().

Provided herein are medical apparatuses and methods and more particularly devices and methods for positioning and anchoring a lining to a hollow body organ, such as a stomach, intestine or gastrointestinal tract. For example, in one embodiment, an endoluminal applier includes a fastening assembly configured to receive tissue and lining, a suction device configured to acquire tissue and lining, and a stitching mechanism configured to stitch into the fastening cavity and to apply a running suture to the tissue portion and lining.

Applier for anchoring a lining to a hollow organ

An implantable system for stimulating the release of satiety hormone in a subject comprises a stimulus device which is implantable in the subject and adapted to apply an electrical stimulus to a tissue of a gastrointestinal system of said subject, and a detection device which is implantable in the subject and adapted to continuously monitoring at least one of a mechanical characteristic and an electrical characteristic of the subject to detect an ingestion of food by said subject, wherein the detection device cooperates with the stimulus device such that the stimulus device applies said electrical stimulus in response to a detected ingestion of food.

Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.

Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods

The present invention relates to an anastomotic device () comprising a first ring () having a first contact surface () and a second ring () having a second contact surface (). The rings () are suitable to be approached in the axial direction (X) such as to move said contact surfaces () towards each other. The anastomotic device is characterized in that the contact surfaces () have an undulated shape relative to a plane (&#x3c0;) perpendicular to the axis (X) of the rings (). According to another aspect thereof, the invention also relates to an apparatus () for the implantation of the anastomotic device (). According to a further aspect thereof, the invention relates to a kit comprising an anastomotic device () and an apparatus () for the implantation of the same.

Anastomotic device

Methods and devices reroute chyme to induce intestinal brake in order to improve the effectiveness of bariatric surgical procedures and to improve comorbidity resolution. A bowel is manipulated to provide a shortened path for chyme to travel to the ileum. These methods and devices of rerouting chyme to induce intestinal brake may include one or more of a surgical procedure, an implanted device, or a combination of an implant with an improved surgical procedure.

Methods and devices for the rerouting of chyme to induce intestinal brake

An instrumentation for performing an endoluminal or transluminal anastomosis, comprises an anastomotic ring device including a proximal ring () having two guide wire seats () adapted to slidably receive two guide wires () and a distal ring () having two guide wire seats () adapted to slidably receive the two guide wires (), the proximal ringand the distal ringbeing snap-connectable to each other, a surgical probe () comprising an elongate insertion shaft () and a probe head () adapted to be endoluminally advanced to a proximal tissue portion (), the insertion shaft () defining guide wire canals () extending into two guide wire exit openings () defined in the probe head () and adapted to deliver the distal ends (&#x2033;) of said guide wires () to said proximal tissue portion (). The distance between the two guide wire exit openings () of the probe () is substantially equal to the distance between the two guide wire seats () of the proximal ring () and to the distance between the two guide wire seats () of the distal ring ().

Surgical instrumentation for performing endoluminal and/or transluminal anastomosis

A surgical stapling instrument comprises a cartridge device with a row of staples and a wavy first tissue interface, and an anvil having a wavy second tissue interface which cooperates with the first tissue interface for clamping tissue therebetween and forming the staples exiting from the cartridge device, a staple driving device adapted to drive the staples out of the cartridge device towards the anvil, wherein the staples are non-symmetrical U-shaped with two legs protruding toward the anvil and a transverse basis connecting the legs, wherein the basis is inclined with respect to the longitudinal direction of the legs and has a length greater than the staple projection on a plane perpendicular to the longitudinal direction of the legs.

Surgical stapling instrument and a staple cartridge and staple for such an instrument

Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.

An anastomotic device () is suitable for approximating and keeping close to each other a first tissue portion () and a second tissue portion () intended to form an anastomosis. The anastomotic device () comprises an abutment portion () suitable for the abutment against a surface of the first tissue portion () and a locking portion () suitable for being placed opposite the abutment portion () with respect to the first and second tissue portion (). The locking portion () and the abutment portion () are mutually connectable through the first and second tissue portions approximated, to keep them connected. The anastomotic device () is suitable for being connected to a guide means comprising at least one guide wire (A, B).

A positioning device for deploying at least one locking portion () of an anastomotic device () for drawing together a first tissue portion () and a second tissue portion () to be connected by means of anastomosis is suitable for sliding along a guide means comprising at least one guide wire (A, B) and comprises an elongated structure (). A head () of the positioning device is suitable to be interference-inserted on a distal end of the elongated structure (). The head () comprises elastic tabs () extending from a proximal end of the head and at least one channel () suitable for receiving a guide wire. The head () comprises a distal end defining a thrust surface () for a locking portion () of the anastomotic device ().

Positioning device for deploying at least one locking portion of an anastomotic device and method for carrying out anastomosis in tracts of the digestive tube

A surgical instrument () for performing controlled myotomies, particularly for performing internal anal sphincterotomies, comprises a proximal handle portion (), an elongate insertion shaft () connected with the handle portion () and extending distally therefrom, a distal incision tip () arranged at a distal end of the insertion shaft () and adapted to incise tissue distally to the insertion shaft (), a lateral incision member () arranged at the insertion shaft () and adapted to incise tissue laterally to the insertion shaft (), wherein the lateral incision member () is movable from a rest position, in which it is retracted towards or inside the insertion shaft () and an operational position in which it protrudes laterally from the insertion shaft ().

Surgical instrument for performing controlled myotomies

Growing community of inventors

Rome, Italy

Alessandro Pastorelli