Boehringer Mannheim Italia, S.p.a.

Boehringer Biochemia Robin S.p.a.

Alessandro Pasini

Silvano Spinelli

Franco Zunino

Carmelo A Gandolfi

Sergio Tognella

Odoardo Tofanetti

Ernesto Menta

Carlo Bugatti

Mariella Valsecchi

Sergio Tongnella

##STR1## Platinum (II) complexes of formula (I) where: Am is a monodentate amine, or (Am).sub.2 is a bidentate amine, B represents a straight or branched alkyl residue or a single bond, R is selected from the group of hydrogen, (C.sub.3 -C.sub.8) cycloalkyl, phenyl or naphthyl which may be substituted by halogens (I, Br, Cl, F), trihalomethane, hydroxyl, (C.sub.1 -C.sub.4)-alkoxyl, (C.sub.1 -C.sub.7)-acylamino, (C.sub.1 -C.sub.7)-sulphamido, allyl, phenoxyl, haloalkoxyl, nitro, cyano, azido, with condition that when R is hydrogen B is different from a single bond, Q is a residue of formula --(CH.sub.2).sub.n1 --CR.sub.a R.sub.b --(CH.sub.2).sub.n2 --, 1,2- or 2,3-naphthalene, benzo-1,3-dioxolan-5,6-diyl, substituted or unsubstituted 1,2-phenylene, R.sub.a and R.sub.b are selected independently of each other from the group of hydrogen, allyl, linear or branched (C.sub.1 -C.sub.8)-alkyl, --(CH.sub.2).sub.p OH, --(CH.sub.2 CH.sub.2 O).sub.q --CH.sub.3, or taken together with the carbon atom to which they are bonded form a (C.sub.3 -C.sub.8) cycloalkyl, or heterocyclic tetrahydropyran-4,4-diyl, n.sub.1 and n.sub.2 are independently zero or the integer 1, p is an integer from 2 to 6, and q is an integer from 1-3, X.sup.- is a biocompatible anion such as chloride, bromide, iodide, nitrate, perchlorate, or one equivalent of sulphate or phosphate, or an anion of a monovalent C.sub.1 -C.sub.4 organic acid such as acetate, propionate or chloroacetate, or of an aromatic acid such as benzoate, or of a heteroaromatic acid such as nicotinate are described. The compounds are useful as anti-tumor drugs.

Cis-platinum complexes with chelating amines and sulphinyl carboxylates

Amino anthracenediones-bis platinum complexes, useful as antitumoral

Platinum(II) complexes, their preparation and use as anti-tumor agents

Amino-anthracenediones-platinum complexes useful as anticancer compounds

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Alessandro Pasini