Fidia Farmaceutici S.p.a.

Fidia S.p.a.

Italian Ministry for Universities and Scientific and Technological

Alessandro Negro

Vincenza Corsa

Lanfranco Callegaro

Susanna Vaccaro

Luciano Messina

Sonia Bisicchia

Francesco Della Valle

Ombretta Stanchi

The present invention relates to a method for the production of hyaluronic acid (HA) inandthrough plasmid vectors wherein the gene is under the control of strong promoter P, and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.

[object Object]

A method of producing hyaluronic acid (HA) inandthrough episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid, are provided.

The present invention relates to a method for the production of hyaluronic acid (HA) inandthrough plasmid vectors wherein the gene is under the control of strong promoter Pgrac, and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.

Method for obtaining recombinant host bacterial cells that produce hyaluronic acid

Expression of osteogenic factor OP-1 in cells of spodoptera frugiperda

This invention relates to a process for obtaining, from transformed cells, the polypeptide called nerve growth factor (.beta.-NGF), and more precisely to the process for obtaining, by recombinant DNA technology using genetic constructions insertible in appropriate eukaryotic cell lines, the biologically active human mature form (.beta.-subunit).

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Padua, Italy

Alessandro Negro