Sanofi

Alessandro Masiero

Laurent Gauthier

Gerald Beste

Nicolas Gourdin

Angela Virone-Oddos

Marielle Chiron

Klervi Desrumeaux

Yanik Bruynooghe

Yanfeng Zhou

Ingo Focken

Benjamin Suratt

Jochen Beninga

Emmanuelle Vigne

Jennifer Kuehn

Leila Sevigny

Sevim Oezguer Bruederle

Alexandre Tang

Charlotte Lahoute

Rami Lissilaa

Sambasiva Rao

Jessica Voss

The present disclosure provides Fc domain variants, including effector-competent Fc domain variants. The present disclosure also provides nucleic acids encoding Fc domain variants and host cells for making Fc domain variants. Methods for increasing the yield of Fc domain variants, and methods of using Fc domain variants to treat disease, are also provided.

Fc variant with enhanced affinity to Fc receptors and improved thermal stability

Provided herein are multispecific binding proteins comprising (a) a first antigen binding domain (ABD) comprising an immunoglobulin single variable domain (ISVD) (e.g., VHH) with binding specificity to CD28; and (b) a second ABD comprising an immunoglobulin heavy chain variable domain (VH) and an immunoglobulin light chain variable domain (VL) with binding specificity to OX40. Also provided are methods of treating autoimmune diseases with said multispecific binding proteins.

CD28/OX40 bispecific antibodies

The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-γ receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).

Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with Fc-engineering

Growing community of inventors

Paris, France

Alessandro Masiero