Speedel Pharma Ag

Francis S.p.a.

Flamma S.p.a.

Alessandro Dondoni

Daniel Bellus

Vittorio Rossetti

Carlo Alberto Bignozzi

Giancarlo Fantin

Alberto Marra

Valeria Dissette

Gian Paolo Negrisoli

Process for the preparation of aryloctanoyl amides

The invention relates to a method for producing trimethobenzamide chlorohydrate. According to such a method, a chloromethilation is carried out on anisle and, after reaction with urotropine followed by acidic hydrolisis, 4-methoxybenzylamide chlorohydrate is obtained which, demethyilated by hydrazoic acid, provides 4-hydroxy benzylamine chlorohydrated that, reacted with 3,4,5-trimethoxybenzoic acid chloride, provides N-(4-Hydroxybenzyl)-3,4,5-trimethoxybenzamide. The latter is per se a novel compound and is also the subject of the invention. This compound is reacted with sodium hydride and N,N-dimethylamino ethyl chloride to provide base trimethobenzamide, the latter being salified with hydrochloric acid.

N-(4-Hydroxybenzyl)-3,4,5-trimethoxybenzamide and method for producing

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Ferrara, Italy

Alessandro Dondoni