Centre National De La Recherche Scientifique

Université Paul Sabatier (Toulouse III)

Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement

Institut National Des Sciences Appliquees De Toulouse

Alessandro De Simone

Stéphanie Heux

Jean-Charles Portais

Disclosed is a microorganism, which has been engineered to acquire methylotrophy. More particularly, the application describes a non-naturally occurring microorganism, which has been engineered to express or include a first enzyme and a second enzyme, wherein the first enzyme is a methanol dehydrogenase (Mdh) enzyme or a methanol oxidase (Mox) enzyme, and wherein the second enzyme is a dihydroxyacetone synthase (Das) enzyme or a transketolase enzyme. The application also describes element and applications, more particularly kits and methods, which include or use the microorganism.

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BARI, Italy

Alessandro De Simone