Centre National De La Recherche Scientifique

Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement

Institut National Des Sciences Appliquees De Toulouse

Universite Toulouse Iii – Paul Sabatier

Alessandro De Simone

Stéphanie Heux

Jean-Charles Portais

Disclosed is a microorganism, which has been engineered to acquire methylotrophy. More particularly, the application describes a non-naturally occurring microorganism, which has been engineered to express or include a first enzyme and a second enzyme, wherein the first enzyme is a methanol dehydrogenase (Mdh) enzyme or a methanol oxidase (Mox) enzyme, and wherein the second enzyme is a dihydroxyacetone synthase (Das) enzyme or a transketolase enzyme. The application also describes element and applications, more particularly kits and methods, which include or use the microorganism.

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BARI, Italy

Alessandro De Simone