Bracco Imaging S.p.a.

Alessandro Barge

Silvio Aime

Valentina Mainero

Fulvio Uggeri

Luciano Lattuada

Roberta Fretta

Enzo Terreno

Dario Livio Longo

Giancarlo Cravotto

Walter Dastrù

Francesca Baricco

The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.

Mechanochemical synthesis of radiographic agents intermediates

The invention concerns a method for obtaining diagnostic images of a human or animal body organ, region, fluid or tissue by using combined X-ray and/or Magnetization Transfer (MT) based MRI techniques and iodinated radiographic compounds as contrast agents, as well as improved Chemical Exchange dependent Saturation Transfer (CESDT or CEST) based MRI procedures in which a iodinated contrast agents is used for in vivo determining a physiological parameter of diagnostic interest.

Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics

The invention discloses the use of ionic and non-ionic radiographic contrast agents for combined X-ray and nuclear magnetic resonance (MRI) diagnostics.

Ionic and non-ionic radiograhic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics

Growing community of inventors

Turin, Italy

Alessandro Barge