Gruppo Lepetit

Alessandro Assandri

Giulio Galliani

Bruno Cavalleri

Giancarlo Lancini

Pietro Consonni

Amedeo Omodei-Sale

Luigi Fontanella

Giancarlo Volpe

Edoardo Martinelli

3,5-diphenyl-1H-1,2,4-triazoles with contragestational activity of the following formula ##STR1## wherein R may be located on one or the other of the two adjacent nitrogen atoms and may represent hydrogen or a group R.sub.5 CO-- wherein R.sub.5 is an aliphatic saturated or unsaturated hydrocarbyl containing from 1 to 20 carbon atoms, R.sub.1, R.sub.2 and R.sub.3, each independently are selected from hydrogen, lower alkyl and lower alkoxy or R.sub.2 and R.sub.3 together may represent a methylenedioxy group, and R.sub.4 is an aliphatic saturated or unsaturated hydrocarbyl group of from 1 to 20 carbons, with the proviso that when R is hydrogen or an R.sub.5 CO-- group wherein R.sub.5 contains 4 or less carbon atoms, R.sub.4 must contain 5 or more carbons. These compounds have proven to be highly effective in terminating pregnancy in several animal species after a single parenteral injection.

3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and uses

New 3-azetidinylethyl-1-phenyl-2-imidazolidinones with neuroleptic activity, their use and methods for their preparation. The azetidinyl group bears alkyl substituents in position 3 and the phenyl group bears halogenated substituents in position 3 and hydroxy group or acylated hydroxy groups in position 4 and/or 6.

Neuroleptic 3-azetidinylethyl-1-phenyl-2-imidazolidinones

The compound 5-[(1-hydroxy-1-methyl)ethyl]-1-methyl-2-nitroimidazole is valuable in combatting Trichomonas vaginalis infections in mammals.

Nitroimidazole derivative with antibacterial activity

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Mariano Comense, Italy

Alessandro Assandri