Philogen S.p.a.

Alessandra Villa

Dario Neri

Giovanni Neri

Jascha-Nikolai Rybak

Christoph Rosli

Sarah Wulhfard

Francesca Pretto

Eveline Trachsel

Roberto De Luca

Laura Gualandi

Catherine Pemberton Ross

Jascha Nikolai Rybak

Catherine Pemberton-Ross

Filippa Fleetwood

Dario Eth-Honggerberg Neri

Eveline Philochem Ag c/oETH-Honggerberg Trachsel

The present application relates to specific binding members that bind carbonic anhydrase IX (CAIX). In particular, the present application relates to the treatment, diagnosis and detection of tumours, e.g. solid tumours, using specific binding members that bind CAIX. The specific binding member may be conjugated to a biocidal or cytotoxic molecule, or to a detectable label.

Antibodies to tumour antigens

The invention relates to the diagnosis and treatment of diseases, including inflammatory disorders, proliferative disorders and autoimmune diseases. The invention provides, and involves the use of, antibody molecules that bind: i) lysozyme, ii) neutrophil elastase, iii) tissue inhibitor of metalloproteinase-1 (TIMP-1), or iv) the D domain of Tenascin-C. The invention also relates to the use of antibody molecules that bind v) the IIICS isoform of fibronectin, vi) the Extra Domain-B (ED-B) of fibronectin, vii) matrix-metalloproteinase 3 (MMP3), or viii) the A1 domain of tenascin-C in the diagnosis and treatment of inflammatory disorders such as inflammatory bowel disease.

Antibodies for treatment and diagnosis of inflammatory bowel disease

The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of lung cancer and lymphoma.

Antigen associated with lung cancers and lymphomas

The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases.

Antigen associated with the neovasculature of tumour metastases

The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumor metastases.

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Milan, Italy

Alessandra Villa