Fidia Farmaceutici S.p.a.

C4t S.c. A.r.l.

Alessandra Topai

Davide Bellini

Stefano Marini

Perla Breccia

Francesca Angeli

Ilaria Cerbara

Francesca Rech

Massimiliano Coletta

Eugenio Claudio Rossano

An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R=NRR, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O&#x2014;, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R, R, R, R=H, SO&#x2014;, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, &#x2014;CO&#x2014;(CH)&#x2014;COOY; Y=negative charge, or H; R=&#x2014;CO&#x2014;CH, H, SO&#x2014;, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R=is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R=is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or Rforms an amide group.

Amides of hyaluronic acid and the derivatives thereof and a process for their preparation

An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R&#x2550;NRR, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O&#x2014;, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R, R, R, R&#x2550;H, SO&#x2014;, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, &#x2014;CO&#x2014;(CH)&#x2014;COOY; Y&#x2550; negative charge, or H; R&#x2550;&#x2014;CO&#x2014;CH, H, SO&#x2014;, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R&#x2550; is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R&#x2550; is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or Rforms an amide group.

Amides of hyaluronic acid the derivatives thereof and a process for their preparation

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Rome, Italy

Alessandra Topai