Newron Pharmaceuticals S.p.a.

Alessandra Restivo

Cibele Sabido-David

Piero Melloni

Emanuela Izzo

Elena Colombo

Simona Francisconi

Patricia Salvati

Carla Caccia

Mauro Napoletano

Florian Thaler

Ermanno Moriggi

Laura Faravelli

Cibele Maria Sabido David

Stefania Vallese

Roberto Forlani

Stefania Nikem Vallese

Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) whereinX, Y, Z, R, R, R, R, R'R, R, R, Rhave the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

Substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives and their use as sodium and/or calcium channel modulators

Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators

Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein

Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) 

Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly useful for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases.

Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly used for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital, and gastrointestinal diseases.

2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented.

2-phenylethylamino derivatives as calcium and/or sodium channel modulators

2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R, R, R, R, and Rhave the meanings as defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urology, and gastrointestinal diseases where the above mechanisms have been described as playing a pathological role, are described. 

This invention is related to compounds of general formula (I) wherein X is oxygen or sulphur or a NRgroup; Ris C-Calkyl, or C-Calkyl substituted by phenoxy or phenyl, both phenoxy or phenyl being optionally substituted by one or more fluoro, chloro, trifluoromethyl, C-Calkyl, hydroxyl, C-Calkoxy; R, Rare independently hydrogen, C-Calkyl, halogen, trifluoromethyl, hydroxy or C-Calkoxy; Ris hydrogen, C-Calkyl; R, Rare independently hydrogen, C-Calkyl, optionally substituted by hydroxy or phenyl; Ris hydrogen or straight or branched C-Calkyl; Het is a five to seven membered, saturated or unsaturated heteromonocyclic or an eight to ten membered, saturated or unsaturated heterobicyclic group, containing one or more heteroatoms chosen independently from nitrogen, oxygen and sulphur, said mono- or bicyclic groups being optionally substituted by C-Calkyl, halogen, hydroxyl or C-Calkoxy; and the pharmaceutically acceptable salts or prodrug thereof, that are active as sodium and/or calcium channel modulators and/or as selective MAO-B inhibitors and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role. 

Substituted benzylaminoalkylene heterocycles

This invention is related to novel cyclopentyl derivatives of the following general Formula (I), wherein X is methylene, oxygen, sulphur or a NRgroup; Ris a straight or branched C-Calkyl or C-Calkenylene or C-Calkynylene chain, optionally substituted with CF, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C-Calkyl, halogens, trifluoromethyl, hydroxy or C-Calkoxy groups; R, Rare independently hydrogen, a C-Calkyl chain, halogen, trifluoromethyl, hydroxy or C-Calkoxy groups; R, RR, Rare independently hydrogen or C-Calkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefor useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

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Milan, Italy

Alessandra Restivo