Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Alessandra Polara

Roger David Norcross

Hans Hilpert

Robert Narquizian

Matthias Heinrich Nettekoven

Emmanuel Pinard

Mark Rogers-Evans

Thomas Johannes Woltering

Guido Galley

Luca Claudio Gobbi

Wolfgang Wostl

Michael Honer

Edilio Boroni

Dieter Murl

The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes. The invention further provides a radio-labelled derivative thereof.

[1,3]oxazines

The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

1,3-oxazines as BACE 1 and/or BACE2 inhibitors

The invention relates to compounds of formula  

Dihydrooxazol-2-amine derivatives

The invention relates to compounds of formula I wherein the definitions of X, R and Rare as defined herein. The compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

Oxazoline derivatives

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Basel, Switzerland

Alessandra Polara