Glaxo Group Limited

Glaxo Wellcome Spa

Alessandra Pasquarello

Fabrizio Micheli

Romano Di Fabio

Barbara Bertani

Silvia Terreni

Yves St-Denis

Giovanna Tedesco

Gabriella Gentile

Anna Maria Capelli

Anna Checchia

Chiara Marchionni

Luca Tarsi

Giorgio Bonanomi

Paolo Dambruoso

Susanna Cremonesi

Stefano Fontana

Fabio Maria Sabbatini

Francesca Cardullo

Yves St Denis

Catia Seri

Bendetta Perini

Benedetta Perini

Romano Di-Fabio

Paola Marzorati

The present invention relates to certain azabicyclo compounds of formula (I)': wherein the various groups are defined herein and that are modulators of dopamine Dreceptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.

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The present invention relates to novel compounds of formula (I) or a salt thereof: wherein

The present invention relates to novel compounds of formula (I) or a salt thereof: wherein Ris a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, Calkyl, haloCalkyl, Calkoxy, Calkanoyl, haloCalkoxy and SF; and n is 1 or 2; their use in therapy, as modulators of dopamine Dreceptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.

Azabicyclo [3. 1. O] hexyl derivatives as modulators of dopamine D3 receptors

The present invention relates to certain azabicyclic compounds of formula (I)': wherein the several groups are defined herein and are modulators of dopamine Dreceptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.

Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors

The present invention relates to compounds of formula (I) or salts thereof wherein A, X, R, Rand n are defined herein, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine Dreceptors, e.g., to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or to enhance cognition.

Spirocompounds useful as modulators for dopamine D3 receptors

The present invention relates to novel compounds of formula (I)' or a salt thereof: wherein and the other groups are define in herein.

Azabicyclo[3.1.0]hex-3-yl}alkyl)pyrimidinedione

The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof wherein

Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists

The present invention relates to tricyclic pyrimidines compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof, to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF).

CRF receptor antagonists

The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof wherein the variables are as defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF) 

Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF)

Compounds of formula (I) or salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethoxy, nitro, cyano, SO R or COR wherein R represents hydroxy, methoxy, amino, alkylamino or dialkylamino; m is zero or an integer 1 or 2; R represents cyano or the group (CH )nCN, &mdash;CH&boxH;CHR , CH )nNHCOCH R or O(CH )pNR R ; R represents cyano or the group COR ; R represents alkoxy or a group NHCOR ; R and R each represent independently hydrogen or alkyl, or R and R together with the nitrogen atom to which they are attached represent a heterocyclic group, or R is hydrogen and R is the group COR ; R represents an alkoxy, amino or hydroxyl group; R represents a hydrogen atom or optionally substituted alkyl, alkoxy, aryl, or heterocyclic group; R is the group R or the group NR R wherein R represents hydrogen or alkyl group; R represents optionally substituted alkyl, aryl, heterocyclic or cycloalkyl group; n is zero or an integer from 1 to 4, p is an integer from 2 to 4, processes for their preparation and to their use in medicine.

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Verona, Italy

Alessandra Pasquarello