Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa

Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Istituto Di Recerche Di Biologia Moleculare P. Angeletti S.p.a.

Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.p.a.

Alessandra Luzzago

Alfredo Nicosia

Riccardo Cortese

Stefano Colloca

Andrew J Bett

Armin Lahm

David C Kaslow

John W Shiver

Emilio A Emini

Paolo Monaci

Franco Felici

Alessandra Vitelli

The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.

Hepatitis C virus vaccine

The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.

Antigen binding proteins directed against scavenger receptor B1 that inhibit HCV replication

A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example, using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the disease, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.

Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable

Process for the preparation of immunogens or diagnostic reagents, and

Growing community of inventors

Rome, Italy

Alessandra Luzzago