Glaxo Group Limited

Smithkline Beecham Corporation

Alessandra Gaiba

Andrew Kenneth Takle

Susan Roomans

Martin Edward Swarbrick

Christopher Norbert Johnson

David Matthew Wilson

David Kenneth Dean

Jason Witherington

Steven James Stanway

Nigel Paul King

Mark Patrick Healy

A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R, R, R, R, R, m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.

[object Object]

A compound of formula (I) or salts thereof, wherein R, R, R, R, n and X are as defined in the specification; a process for preparing such compounds, a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.

Compounds

The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, Rand Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors. Pharmaceutical compositions comprising the compounds methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.

Piperazine derivatives useful for the treatment of gastrointestinal disorders

Compounds of formula (I):wherein X is O, CH, S or NH, or the moiety X&#x2014;Ris hydrogen;

Imidazol-2-carboxamide derivatives as raf kinase inhibitors

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Harlow, United Kingdom

Alessandra Gaiba