Bia Separations D.o.o.

Baxter Healthcare Sa

Octapharma Ag

Bluesky Immunotherapies Gmbh

Bia D.o.o. Laboratory and Process Equipment Co., Ltd.

Sartorius Bia Separations D.o.o.

Ales Strancar

Djuro Josic

Milos Barut

Ales Podgornik

Primoz Koselj

Ales Podgronik

Manfred Reiter

Thomas Muster

Alois A Jungbauer

Markus Wolschek

Rainer Hahn

Peter Stanley Gagnon

Elisabeth Roethl

Matjaz Peterka

Marko Banjac

Mojca Tajnik Sbaizero

Petra Kramberger

Sara Drmota Prebil

Maja Leskovec

Rok Zigon

Elisabeth Maurer

The present invention refers to a process for purifying virus particles from cell culture, comprising the steps of subjecting the cell culture to centrifugation to get a supernatant fraction of virus particles, incubating said fraction with a nuclease, diluting the fraction with low conductivity buffer, subjecting said diluted fraction to a SO3 chromatography step, performing a washing step with low conductivity buffer, and eluting virus particles.

SO3 chromatography for use in a method for virus purification

A process for the purification of influenza virus or derivative thereof requires providing a source of influenza virus or derivative thereof, optionally subjecting the source to a pre-purification step, followed by subjecting the source to at least one chromatographic step on chromatographic material selected from the group consisting of porous particles having mean pore sizes of at least 20 nm, perfusion particles, gel-in-a-shell particles, tentacle like particles, membrane adsorbers, and monoliths, and collecting fractions eluted from the chromatographic material that contain the influenza virus or derivative thereof, excluding sulfuric ester of cellulose or cross-linked polysaccharides.

Method for influenza virus purification

Disclosed is a process for preparing agents containing virus-inactivated vitamin K-dependent plasma components as well as protein C, protein S, factors II, VII, IX and/or X as well as combinations thereof, such as, for example, PPSB preparations, wherein a source containing these components is subjected to a appropriate separation procedures, especially by using membrane-chromatographic methods.

Process for preparing virus-inactivated factors 1X and X by membrane chromatography

Chromatographic device

Chromatography material and a process of manufacturing that material

A device for the rapid separation and/or conversion of substrates is disclosed herein. The device include a porous tube (,) disposed inside a tubular sample distributor (,). The tubular sample distributor (,) includes channel structures on its inner surface and is disposed inside a tubular body (,). A tubular sample collector (,) having channel structures on its outer surface is disposed inside the porous tube (,). A circular sample distributor (,) is provided having a circumferential portion and radially extending grooves in conjunction with the channel structures of the tubular sample distributor (,). A circular sample collector (,) is also provided having a circumferential portion and radially extending grooves in conjunction with the channel structures of the tubular sample collector (,). The hollow body (,) is arranged between securing means (,) that provide a sample inlet and outlet in communication with the circular sample distributor (,) and circular sample collector (,), respectively.

Device for the rapid separation and/or conversion of substrates

An apparatus for the conversion of substrates both for analytical and preparative purposes in a flow-through and cross-flow reactor having compact porous discs and/or compact porous tubes as carrier for conversion reaction or preparative separations which compact porous discs and/or compact porous tubes are modified with substances being capable of specifically binding and/or converting said substrates by distributing the samples to be converted and/or preparatively separated and collecting the converted and/or separated substrates preferably in a low volume, wherein the distribution of the sample does not affect the carrier adversely.

Porous tube filter

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Ljubljana, Slovenia

Ales Strancar