Alphora Research Inc.

Sandoz Ag

Alena Rudolph

Boris Gorin

Fabio E S Souza

Ming Pan

Dino Alberico

Ricardo Orprecio

Jason A Bexrud

Huzaifa Rangwala

Teng Ko Ngooi

Robert Jordan

Fabio ES Souza

Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed. 

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Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein

Disclosed is a compound of formula 1, as shown below, where R, R, R, R, R, Rand Rare as described herein. Also, disclosed is a process for the preparation of compounds of formula 1, and intermediates used therein. The compound of formula 1 can be useful for preparation of halichondrin analogs such as Eribulin. 

2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation

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Puslinch, Canada

Alena Rudolph