Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu

Spofa, Spojene Podniky Pro

Tessek Sdruzeni Praha

Alena Roubalova

Evzen Kasafirek

Miroslav Rybak

Ivan Krejci

Premysl Fric

Jiri Vanzura

Jan Slaby

Antonin Sturc

Jitka Houskova

Cyril Losticky

Stanislav Ulrych

Michal Bartik

Oldrich Sedlmaier

Evzen Krepela

The claimed invention concerns concentrates of coagulation factors II, VII, IX and X and the method of their preparation by selective adsorption on an equilibrated carrier of hydroxyethylmethacrylate or hydroxyethylacrylate with bound diethylaminoethyl groups, followed by selective elution. The concentrates of coagulation factors II and X can be used to detect coagulation factor VII and in a laboratory method for the detection or determination of the extent of mammalian inflammatory diseases.

Concentrates of coagulation factors II, VII, IX and X, method of their

Peptide ester and amide derivatives of the general formula I: ##STR1## in which X is H or an acyl, A and B are structurally defined amino acid residues, n is an integer of from 1 to 3, R.sup.1 is H or a lower alkyl and either R.sup.2 or C is a defined optionally modified amino acid residue and the other is a lower alkoxyl, an amino group or a direct chemical bond, are converted under physiologic conditions, by enzymic hydrolysis in pathologically altered tissues and subsequent spontaneous cyclization, into pharmacodynamically active spirocyclic peptide derivatives of the general formula III: ##STR2## in which R.sup.3 and R.sup.4 are H atoms, optionally substituted alkyl groups or jointly an aliphatic chain forming preferably a 2,5- piperazinedione ring, and hence can act as pro-farmaca (drug precursors) of prolonged biological effect.

Peptide derivatives and processes for their preparation

A method is described for the preparation of novel alkylamides of carboxyalkanoyl peptides of the formula ##STR1## wherein R is an aralky or an alkyl group of 1-5 carbon atoms, A is a residue of peptidically bound proline or alanine, B is a straight bond or a residue of peptidically bound proline or alanine and X is a CH.dbd.CH group or a methylene group of 1-3 carbon atoms. The described compounds are capable of inhibiting elastase.

Alkylamides of carboxyalkanoyl peptides and method for preparation

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Prague, Czechia

Alena Roubalova