Valneva Austria Gmbh

Intercell Ag

Alena Egyed

Walter G Schmidt

Karen Lingnau

Frank Mattner

Michael Buschle

Carola Wenander

Wolfgang Zauner

Jörg Fritz

Carola Schellack

Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I), wherein any NMP is a 2' deoxynucleoside monophosphate or monothiophosphate, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, -6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine-monophosphate or -monothiophosphate, NUC is a 2&#x2032; deoxynucleoside, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, 6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine, any X is O or S, a and b are integers from 0 to 100 with the proviso that a+b is between 4 and 150, B and E are common groups for 5&#x2032; or 3&#x2032; ends of nucleic acid molecules, as well as a pharmaceutical composition containing such ODNs.

Methods and compositions involving immunostimulatory oligodeoxynucleotides

Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I) 

Described is a vaccine which comprises at least one antigen and at least one cathelicidin derived antimicrobial peptide or a derivative thereof as well as the use of a cathelicidin derived antimicrobial peptide or a derivative thereof for the preparation of an adjuvant for enhancing the immune response to at least one antigen.

Method of vaccination comprising administering an antigen and a cathelicidin derived antimicrobial peptide

The invention relates to a composition comprising

Growing community of inventors

Vienna, Austria

Alena Egyed