Schering Corporation

Akermin, Inc.

Aleksey Zaks

William Brian Morgan

Brett M Rambo

Viyyoor Moopil Girijavallabhan

Ashit K Ganguly

Anil K Saksena

Raymond G Lovey

Yi-Tsung Liu

Russell E Pike

Haiyan Wang

Michael J Homann

Tracy L Bucholz

John Reardon

Luke E Weber

Alexander J Linder

Dawn C Powell

Caroline M H Duesing

The present invention generally relates to immobilized biocatalysts or immobilized enzymes for use in carbon capture and sequestration technology. Thiol-ene chemistry is used to couple a biocatalyst, particularly carbonic anhydrase, to a substrate including a substrate, a solid support, a microparticle, a nanoparticle, or a combination thereof.

Thiol-ene coupling chemistry for immobilization of biocatalysts

The present invention generally relates to improvements in enzyme immobilization, particularly for use in the field of carbon dioxide capture and sequestering. It has been discovered that the utilization of sol-gel processes to immobilize enzymes in polysilicate-polysilicone copolymer coatings and particles, and the deposition of these coatings on solid state supports or use of suspensions of these particles, provides significant benefits for use in industrial applications involving enzymatic catalysts.

Polysilicate-polysilicone enzyme immobilization materials

Enantioselective enzymatic hydrolysis of 3-substituted esters of glutaric acid

Disclosed is a process for preparing chiral compounds of the formula (I) ##STR1## wherein: X.sup.1 and X.sup.2 are independently F or Cl; and E is --SO.sub.2 R.sup.2, wherein R.sup.2 is C.sub.1 -C.sub.6 alkyl, --C.sub.6 H.sub.4 CH.sub.3 or --CF.sub.3 ; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of the formula ##STR2## wherein: X.sup.1 and X.sup.2 are independently F or Cl; B represents --C(O)Q* or --CH.sub.2 OR'; Q* represents a chiral auxiliary group; R' represents a hydroxy protecting group selected from --CH.sub.2 C.sub.6 H.sub.5, or --C(O)R.sup.1, wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl; and A represents Cl, Br, I or triazolyl; are also disclosed.

Process for preparing intermediates for the synthesis of antifungal

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Hoboken, NJ, United States of America

Aleksey Zaks