Ecole Polytechnique Federale De Lausanne

Roche Sequencing Solutions, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Aleksandra Radenovic

Jiandong Feng

Ke Liu

Yann A Astier

Lorenz Jan Steinbock

The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

Nanopore forming method and uses thereof

An osmotic power generator comprising an active membrane supported in a housing, at least a first chamber portion disposed on a first side of the active membrane for receiving a first electrolyte liquid and a second chamber portion disposed on a second side of the active membrane for receiving a second electrolyte liquid, a generator circuit comprising at least a first electrode electrically coupled to said first chamber, and at least a second electrode electrically coupled to said second chamber, the first and second electrodes configured to be connected together through a generator load receiving electrical power generated by a difference in potential and an ionic current between the first and second electrodes. The active membrane includes at least one pore allowing ions to pass between the first and second sides of the membrane under osmosis due to an osmotic gradient between the first and second electrolyte liquids to generate said difference in potential and ionic current between the first and second electrodes.

Osmotic power generator

Molecular sensing system including: a sensing device () comprising at least one support layer (), and an active layer () mounted on said support layer and having at least one nano-pore () configured for translocation of a molecular analyte () therethrough; an electrically conducting liquid () in contact with the active layer in a region around said nano-pore; and a signal processing circuit () comprising an ionic current circuit () configured to generate and measure an ionic current (Ii) in the electrically conducting liquid influenced by the translocation of the molecular analyte through the nano-pore. The molecular sensing device of the invention allows for single-nucleotide discrimination and detection of the specific sequence within ssDNA.

Molecular sensing device

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St. Sulpice, Switzerland

Aleksandra Radenovic