Vertex Pharmaceuticals, Inc.

Aleksander Szymaniak

Christopher D Thanos

George Harb

Chunhui Xie

Evrett Thompson

Rebecca Chinn

Suyash Raj

Bryce W Carey

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

Stem cell derived pancreatic islet differentiation

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Boston, MA, United States of America

Aleksander Szymaniak