Centro De Ingenieria Genetica Y Biotecnologia

Alejandro Moro Soria

Alicia Santos Savio

Ricardo Silva Rodriguez

Osvaldo Reyes Acosta

Silvio Ernesto Perea Rodriguez

Nelson Francisco Santiago Vispo

Yaquelin Puchades Izaguirre

Luis Javier González López

Haydee Geronimo Perez

Luis Javier Gonzalez Lopez

Yanelis Morera Diaz

Armando Alexei Rodriquez Alfonso

Jose Rafael Martinez Castillo

Silvio Ernesto Perea Rodriquez

Belkis Gonzalez Barrios

Belkis González Barrios

Yaquelín Puchades Izaguirre

Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the immunized host. IL-15 can be presented in this vaccine composition either alone or coupled to a carrier such as the P64k protein with a vaccine adjuvant such as Aluminum hydroxide. Besides, this invention is related to the use of this vaccine for treatment of Rheumatoid arthritis and other IL-15 over-expressing related diseases, and leukemia, where this cytokine acts as a growth factor.

Vaccine composition comprising interleukin-15 (IL-15)

This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules.

Peptides for the treatment of cancer associated with the human papilloma virus (HPV) and other epithelial tumors

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Ciudad de la Habana, Cuba

Alejandro Moro Soria