Altria Client Services LLC

Philip Morris USA Inc.

Philip Morris Products S.a.

Alec J Hayes

Chengalrayan Kudithipudi

Robert Frank Hart, Iii

Jason W Flora

Maria Shulleeta

Dongmei Xu

Yanxin Shen

Jesse Frederick

Rutger S Van Der Hoeven

Marcos Fernando De Godoy Lusso

Jerry Whit Morris

Greg Davis

Kenny Lion

Rutger Van Der Hoeven

This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.

Tobacco having altered leaf properties and methods of making and using

Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

Genetic locus imparting a low anatabine trait in tobacco and methods of using

Various embodiments are directed to consumable products incorporating a matrix of cultured tobacco cells. Any tobacco variety may be utilized for establishing in vitro tobacco cultures, including native tobacco varieties and genetically modified tobacco varieties derived from any tobacco variety. Various embodiments are directed to methods for producing tobacco products incorporating cellular material and/or extracts derived from tobacco cells cultured in vitro.

Cultured tobacco cells as a matrix for consumable products

This disclosure provides tobacco plants containing a PMT RNAi and tobacco plants having a mutation in PMT, and methods of making and using such plants.

Methods of curing tobacco that reduce the levels of TSNAs and/or improve leaf quality are described herein.

Methods of reducing tobacco-specific nitrosamines (TSNAs) and/or improving leaf quality in tobacco

Various embodiments are directed to transgenic plants, including transgenic tobacco plants and derivative seeds, genetically modified to impede the transport of Cadmium (Cd) from the root system to aerial portions of transgenic plants by reducing the expression levels of HMA-related transporters. Various embodiments are directed to transgenic tobacco plants genetically modified to stably express a RNAi construct encoding RNAi polynucleotides that enable the degradation of endogenous NtHMA RNA variants. Reduced expression of NtHMA transporters in transgenic plants results in substantially reduced content of Cadmium (Cd) in the leaf lamina. Various consumable products that are substantially free or substantially reduced in Cd content can be produced by incorporating leaves derived from transgenic tobacco plants modified to reduce the expression of NtHMA transporters.

Growing community of inventors

Chesterfield, VA, United States of America

Alec J Hayes