Cellgate, Inc.

Wisconsin Alumni Research Foundation

Progen Pharmaceuticals, Inc.

Other

Slil Biomedical, Corporation

Aldonia L Valasinas

Laurence J Marton

Venodhar K Reddy

Andrei V Blokhin

Benjamin J Frydman

Hirak S Basu

Yu Albert Wang

Aparajita Sarkar

Linda Clifford, Legal Representative

Donald T Witiak

Vendohar K Reddy

Subhra Bhattacharya

Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.

Oligoamine compounds and derivatives thereof for cancer therapy

Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.

Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor

Conjugates in which polyamine analogs are conjugated to an amino acid are provided, as well as compositions comprising these conjugates. Methods of using these conjugates as anticancer treatments are also provided.

Polyamine analog-amino acid conjugates useful as anticancer agents

Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.

Conformationally restricted polyamine analogs as disease therapies

Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conjugate compounds are also disclosed.

Porphyrin-polyamine conjugates for cancer therapy

Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to, porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.

Growing community of inventors

Madison, WI, United States of America

Aldonia L Valasinas