Gruppo Lepetit

Aldo Trani

Adriano Malabarba

Romeo Ciabatti

Bruno Cavalleri

Ambrogio Magni

Paolo Strazzolini

Pietro Ferrari

Clelia M Dallanoce

Giorgio Tarzia

Beth P Goldstein

Pierfausto Seneci

Luigi Simioni

Sergio Bellini

Compound of general formula V ##STR1## wherein Hal is a chlorine or bromine atom. The compounds are useful as starting materials in preparing gamma-rubromicin amino derivatives.

7'-amino-naphthazarin antibiotic derivatives

New naphthazarin derivatives obtained by introducing in the 7' position of Purpuromycin or .gamma.-Rubromycin an amino or a monosubstituted amino group. The compounds of the invention show antibiotic activity against Gram positive and Gram negative microorganisms, fungi and protozoa and are suitable for the treatment of vaginal infections.

The present invention is directed to a new class of teicoiplanin derivatives, a process for preparing them and their use as pharmaceutically active substances.

O.sup.56 -alkyl derivatives of aglycone and pseudo aglycones of

The present invention is directed to new de-(acetylglucosaminyl)-di(dehydro)deoxy teicoplanin derivatives which possess antibiotic activity mainly against gram positive bacteria. The new compounds are obtained by chemical modification of a teicoplanin antibiotic substance.

De-(acetylglucosaminyl-di(dehydro)-deoxy teicoplanin derivatives

Water soluble salts of purpuromycin, their use for the topical treatment of infectious vaginitis and topical dosage forms containing said products. Oral and parenteral formulations for administration of the water soluble purpuromycin salts. The water soluble salts of purpuromycin are simultaneously active against the main causative agents of infectious vaginitis i.e.: Candida vaginalis, Trichomonas vaginalis and Gardnerella vaginalis.

Water soluble salts of purpuromycin and pharmaceutical formulations

Carboxylic acid ester derivatives or deglucoteicoplanin

The present invention is directed to ester derivatives at the carboxylic function of the glycopeptidic antibiotic substance called antibiotic L 17046 with antimicrobial activity mainly against gram-positive bacteria.

Ester derivatives of antibiotic L 17046

The present invention is directed to new de-(acetylglucosaminyl-di(dehydro)deoxy teicoplanin derivatives which possess antibiotic activity mainly against gram positive bacteria. The new compounds are obtained by chemical modification of a teicoplanin antibiotic substance.

De-(acetylglucosaminyl)-di(dehydro)-deoxy teicoplanin derivatives

New process for preparing olefinic lactams by decomposing the corresponding N,N-dimethyl-N-oxides in a suitable solvent in the presence of a base at a temperature of at least 100.degree. C.

Process for decomposing N-oxide derivatives producing

2-(Pyrrol-1-yl)amino-4,5-dihydro-1H-imidazole derivatives of the following general formula I ##SPC1## wherein R, R.sub.1, R.sub.2 and R.sub.3 may be the same or different and are independently selected from the class consisting of hydrogen, lower alkyl, carbo-lower alkoxy, phenyl, substituted phenyl, R.sub.4 represents hydrogen or lower alkyl, n is an integer and may be 2 or 3. The corresponding pharmaceutically acceptable acid addition salts of the substances of formula I above are considered as a part of the invention. The invention compounds display very interesting anthypertensive properties.

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Milan, Italy

Aldo Trani