Istituto Luso Farmaco D'italia

Istituto Luso Farmaco D'italia S.r.l.

Instituto Luso Farmaco D'italia S.r.l.

Other

Menarini Ricerche S.p.a.

Berlin-chemie Ag

Menarini Richerche S.p.a.

Lusofarmaco Istituto Lusofarmaco D'italia Spa

Aldo Salimbeni

Elso Manghisi

Carlo Scolastico

Davide Poma

Carlo Alberto Maggi

Stefano Manzini

Giancarlo B Fregnan

Renato Canevotti

Damiano Turozzi

Jacques Mizrahi

Pietro Mennella

Giuseppe Cascio

Fabio Paleari

Giovanni Ferni

Francesco Fici

Saturnino Caliari

Anna Renzetti

A new process for the preparation of bicyclic peptide compounds Formula (I) in high yields of high purity, useful as intermediates for preparing compounds with pharmacological activity, is described. 

Process for the preparation of bicyclic peptide compounds

Process of preparing (E)-5-(2-bromovynyl)-2'-deoxyuridine (Brivudine) characterized in that halogen-free solvent selected form esters or cyclic ethers are used in the bromination step of 5-ethyl-2&#x2032;-deoxyuridine diacylate. The use of solvents is advantageous in respect of toxicity, discharge costs and environment protection.

Process for the preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine

N-3 substituted pyrimidin-4-ones with AII antagonistic activity

Derivatives of bicyclic heterocycles comprising a pyrimidone ring fused to another 5, 6, or 7 membered nitrogen heterocycle which is C-substituted, through a methylene bridge, by a biphenyl group.

Pyrimidinone derivatives fused to nitrogen heterocycles having a II

Imidazole derivatives having a II antagonist activity

This invention relates to diltiazem analogs having the formula: ##STR1## where the substituents are defined in the specification. These compounds are useful in treating cardiovascular problems. The invention also relates to a process for preparing the compounds and to pharmaceutical compositions containing the compounds.

1,5 benzothiazepinone dervatives their preparation and pharmaceutical use

Compounds having angiotensine II antagonistic activity

Imidazole ethers having a II antagonist activity

Invention concerns 4,5-bisubstituted-2-imidazolone derivatives of formula I ##STR1## and pharmaceutically acceptable salts thereof, having high affinity in vitro for D.sub.2, 5-HT.sub.2, .sub.1 receptors and in vivo activity on central nervous system and antihypertensive activity with negligible secondary effects; methods for the preparation thereof; pharmaceutical formulations containing them.

Imidazolone derivatives with activity on central nervous system and

2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives of formula (I): ##STR1## and pharmaceutically acceptable salts thereof having in vitro high affinity and selectively for .alpha..sub.1 receptors and in vivo good and long lasting hypotensive activty, with negligible side-effects; processes for the preparation thereof and pharmaceutical compositions therefrom.

2,2-disubstitued 2,3-dihydro-1,4-benzodioxin derivatives having

This invention relates to a series of thiazole derivatives having the general formula ##STR1## The compounds of the invention have an interesting diuretic activity and low toxicity.

(2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having

3-(3-Hydroxybutoxy)-1-butanol having formula II and its stereoisomers and optical isomers, at the pure state, are described ##STR1## Processes for the purification of II and for the preparation of a pure diastereoisomer of II are described. Pharmaceutical compositions containing as the active ingredient compound II alone or combined with the isomeric ethers 4-(3-hydroxybutoxy)-2-butanol I and 3-(3-hydroxy-1-methylpropoxy)-1-butanol III.

3-(3-Hydroxybutoxy)-1-butanol in pharmaceutical compositions

The invention provides novel esters of 1-(p-hydroxyphenyl)-2-(1'-methyl-2'-phenoxyethylamino)-1-propanol having better properties as vascular dilatators, than the corresponding 1-(p-hydroxyphenyl)-2-(1'-methyl-2-phenoxyethylamino)-1-propanol.

Esters of

2,2-Disubstituted-1,3-benzodioxoles having anti-inflammatory, analgesic, antipyretic and antitussive action, inhibition or excitation of the central nervous system, local anaesthetic, anti-arrhythmic and anti-hypotensive action, and action inhibiting the aggregation of platelets.

2,2 Disubstituted-benzodioxoles

1,4-Benzodioxan derivatives of the formula: ##STR1## IN WHICH Ar is an aryl group and X is --OR, where R is hydroxyalkyl, aminoalkyl, or aminoalkoxyalkyl, or ##STR2## where R.sub.1 and R.sub.2 are hydrogen, hydroxyl, alkyl, aryl, or aralkyl or are joined together to form an alkylene group which may contain an oxygen, sulphur or nitrogen hetero atom, have interesting pharmacological properties.

Growing community of inventors

Milan, Italy

Aldo Salimbeni