Giuliani S.p.a.

Gipharmex S.p.a.

Centre National De La Recherche Scientifique

Université Louis Pasteur De Strasbourg

Connecticut College

Alfa Wassermann, Inc.

Erregierre Industria Chimica S.p.a.

R.d. Pharmadvice S.r.l.

Aldo Roda

Roberto Pellicciari

Giuliano Frigerio

Raymond Ziessel

Loïc Charbonniere

Virginio Castagnola

E Giuliano Frigerio

Massimo Guardigli

Nicolas Weibel

Elisa Michelini

Jennifer P DeAngelis

Tara L Southworth

Bruce R Branchini

Egidio Marchi

Egidio Molinari

Silvano Piani

Antonio Bonaldi

Gianfranco Cainelli

Nicoletta Crespi Perellino

Anacleto Minghetti

Danila Ingrid Marchioretto

Bruno Danieli

Maria R Milani

Enrico Roda

Claudio Trombini

Mara Mirasoli

Arianna Quintavalla

Massimo Di Fusco

The present invention relates to an isolated nucleic acid and polypeptide sequence that encodes for a luciferase of, as well as mutants thereof. The luciferase proteins of the present invention have been found to have extended bioluminescence emission that is red- or blue-shifted, and are useful as a bioluminescent marker or as an additive to selected materials.

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The invention relates to compounds, to the complexes they form with a lanthanide, and to the use of the complexes for fluorescence marking or NMR imaging. The complex consists of an Ln ion and a ligand R&#x2014;C(X&#x2014;R)(R)&#x2014;NRR. Ris a functional group, X is a single bond or a hydrocarbon-based chain consisting of at least one alkylene or alkenylene group optionally comprising at least one hetero atom or an arylene. Ris an anionic group Aor a C-Calkylene or alkenylene group bearing at least one such group Aand optionally comprising at least one hetero atom. Ris H or a C-Calkylene or alkenylene group optionally containing at least one hetero atom, and optionally bearing at least one anionic group A. Ris a substituent with light-absorbing properties that forms chelate rings with Ln. Ris a substituent that forms chelate rings with Ln.

Lanthanide complexes, preparation and uses thereof

Lanthanide complexes preparation and uses thereof

Compounds with an antioxidant activity, compositions useful as food integrators containing them and process for their preparation

An amide of formula ##STR1## and its pharmacologically acceptable organic or inorganic salt shows a metabolic stability, both enteric and hepatic, greater than that of the corresponding bile acids conjugated with glycine or taurine physiologically present in the enterohepatic circulation. The pharmacological activity of the compounds of formula I or their pharmacologically acceptable organic or inorganic salt makes the use effective for the therapy of biliary calculosis from cholesterol and in every pathology caused by cholestasis like chronic hepatitis from cholestasis, primitive biliary cirrhosis and juvenile hepatopathy associated with cystic fibrosis.

Bile acids derivatives useful in the therapy of the biliary calculosis

A process for the preparation of glycine-conjugated bile acids as general formula (I):

Process for the preparation of glycine-conjugated bile acids

Compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by fluorination of the suitably protected 6.alpha.-hydroxy-7-keto-derivatives.

Fluorinated bile acid derivatives, processes for the preparation thereof

Compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by reacting with succinic acid carboanions the corresponding derivatives which have previously been protected, and subsequently deprotecting and decarboxylating them.

Bile acid derivatives, processes for the preparation thereof and

Bile acid derivatives of formula I ##STR1## wherein: R is hydrogen or hydroxy;

Bile acid unsaturated derivatives and pharmaceutical compositions

A compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by fluorination of the suitably protected 6-hydroxy-7-keto-derivatives.

Compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by reacting with succinic acid carbonanions the corresponding derivatives which have previously been protected, and subsequently deprotecting and decarboxylating them.

New derivatives of chenodeoxycholic, ursodeoxy cholic, cholic and ursocholic acids, bearing a methyl group in the side chain in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described. The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.

Derivatives of biliary acids, process for the production thereof and

The present invention relates to a complex of products useful for the not-invasive and rapid treatment of the biliary calculosis of cholesterolic nature. It is based upon the coupling of a special apparatus generating medium-energy or medium-low-energy ultrasounds with pharmaceutical compositions based on biliary acids, capable of de-saturating bile super-saturated with cholesterol.

Complex of products for the rapid and not-invasive treatment of biliary

Compounds of formula I ##STR1## wherein: R.sub.1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in .alpha. or .beta. configuration, are useful in human therapy. Compounds I are prepared by methylation of the corresponding appropriately protected 7-keto-derivatives.

Biliary acid derivatives, processes for the preparation thereof and

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Bologna, Italy

Aldo Roda