Istituto Chemioterapico Italiano

Cometec S.r.l.

Aldo Garzia

Andrea Bottazzi

Robert D Williams

Giorgio Vittadini

William Ferrari

Umberto Bucci

Costantino Coccoli

Domenico Pelagalli

The growth rate of an animal is stimulated by administering to the animal a growth promoting amount of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, are each selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms and halogen; X is selected from carbonyl and a ketal group of the formula ##STR2## wherein R.sub.6 and R.sub.7, which can be the same or different, are each selected from hydrogen and alkyl having 1 to 3 carbon atoms; A is a linear or branched alkylene having from 1 to 8 carbon atoms; and R.sub.8 and R.sub.9, which can be the same or different, are each selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, or 2-hydroxy-alkyl wherein the alkyl group has 2 to 4 carbon atoms, or R.sub.8 and R.sub.9, together with the nitrogen atom, form a heterocyclic ring optionally including other heteroatoms; provided that, when X is a ketal group and A is ethylene, the radical ##STR3## is a group other than morpholino.

Methods and compositions for promoting growth of animals

Compounds corresponding to the formula: ##STR1## where R is an alkyl group of 3 to 5 carbon atoms, are useful in treating alcohol dependence.

.alpha.-Amino-.gamma.-butyrolactones for treating alcohol dependence

There is disclosed the reduction of alkyl esters of carbonic-carboxylic acid anhydrides at elevated temperature and pressure in the presence of platinum group metal catalysts, especially palladium on activated carbon, to make alcohols. Novel alkyl esters of carbonic-carboxylic acid anhydrides are disclosed, and can be used to make the corresponding alcohols, e.g., substituted benzyl alcohols. The alcohols can be converted to the corresponding halo, e.g., chloro, compounds. The substituted benzyl halides can be reacted with di(lower alkoxy)propionitriles, and the resulting 5-benzyl pyrimidines such as trimethoprim, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine, which is a known anti-bacterial agent, are especially useful in combination with sulfa drugs such as sulfamethoxazole. Other alcohols that can be made in accordance with the invention include 2,6-pyridine dimethanol which can be used to make pyridinol carbamate, an anti-inflammatory agent and an anti-arteriosclerotic agent and 1-aceto-4-hydroxymethyl-5-methyl imidazole, which can be converted into cimetidine.

Reduction of alkyl esters of carbonic-carboxylic anhydrides to alcohols

Compounds of the formula ##STR1## wherein A is alkylene, R.sub.1, R.sub.2, and R.sub.3 are hydrogen or lower alkoxy, and R.sub.4 is ##STR2## in which R.sub.5 and R.sub.6 are hydrogen or lower alkyl, with the proviso that at least one of R.sub.5 and R.sub.6 is lower alkyl, and &gt;X is oxygen, ##STR3## or &gt;N--R.sub.7 wherein R.sub.7 and R.sub.8 are hydrogen or lower alkyl, depress the activity of the central nervous system when administered to a living animal.

Morpholine compounds and methods of use

Compositions and method for combatting swine dysentery using substituted quinoxalines represented by the formula: ##STR1## where R is hydrogen or lower alkyl of 1 to 5 carbon atoms, e.g., methyl and pentyl, are provided.

Product and method for combatting swine dysentery

Compositions and a method for combatting cholera using novel substituted quinoxalines represented by the formula ##STR1## where R is hydrogen or lower alkyl of 1 to 5 carbon atoms, e.g., methyl to pentyl, are provided. A process for preparing the compounds is also provided.

Quinoxaline compound and composition, process for preparing compound,

A composition of cysteamine and a compound represented by the formula ##SPC1## Where R is hydrogen, --CHO or ##EQU1## useful for the treatment of an animal infected with a virus.

Treatment of viral infections

This invention relates to 2-amino-4-[2-(1-lower alkyl-5-nitro-2-imidazolyl)vinyl]-pyrimidines and their use in the treatment of protozoal diseases and bacterial infections.

2-Amino-4[2-(1-lower alkyl-5-nitro-2-imidiazolyl)vinyl]pyrimidines for

Compounds corresponding to the formula: ##EQU1## where R is an alkyl group of 3 to 5 carbon atoms are anticonvulsants and sedatives.

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Milan, Italy

Aldo Garzia