Universitatsspital Basel

Eth Zurich

Biotronik Ag

Hylomorph Ag

Aldo Ferrari

Dimos Poulikakos

Tobias Lendenmann

Maximilian Fischer

Simone Bottan

Martin Grapow

Bernhard Winkler

Friedrich Eckstein

Alexander Borck

Alexander Rzany

Bjoern Klocke

Jens Ulmer

Matthias Gratz

Robert Schmiedl

Vartan Kurtcuoglu

Philipp Schoen

Francesco Robotti

Benjamin Josi

Björn Klocke

Philipp Schön

The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.

Artificial vascular graft

A method for the self-assembled production of a topographically surface structured cellulose element. First, a mold is provided having on one side a first surface which is in a complementary manner topographically structured and which is permeable to oxygen. Next, a liquid growth medium containing cellulose producing bacteria is provided. Then, the mold is placed to form a interface such that the side of the mold with the first surface is in direct contact with the liquid growth medium, and an opposite side is facing air or a specifically provided oxygen containing gas surrounding. This allows bacteria to be produced and deposit cellulose on the first surface and developing on the interface a surface structured surface complementary thereto, until a cellulose layer with a thickness of the element of at least 0.3 mm is formed. Finally; the element is removed from the mold.

Method for the production of structured cellulose patches or elements and devices made using such a method

The present invention refers to an implant with a surface layer having a topographic modification. The topographic modification includes a line pattern with ridge and groove widths of 0.9 to 1.1 &#x3bc;m and a ridge height of more than 0.9 &#x3bc;m.

Implant with a surface layer having a topographic modification

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Zurich, Switzerland

Aldo Ferrari