Indena S.p.a.

Indena S.a.

Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Inverni Della Beffa Industria Chimico Farmeceutica Derivati Naturali

Aldo Cristoni

Ezio Bombardelli

Paolo Morazzoni

Gabriele Fontana

Enrico Mercalli

Ezio Bombarrdelli

Roberto Seghizzi

Bruno Gabetta

Piero Foresta

Orlando Ghirardi

The invention relates to a process for cosmetic treatment, including the reduction of superficial and deep wrinkles, using ferutinine fromspp extracts.

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The invention relates to a process for the preparation of ferutinine (Ia) fromspp extracts comprising basic hydrolysis of the extracts and treatment with p-pivaloyloxybenzoic acid. The invention relates also to the use of the extracts and ferutinine in the cosmetic and dermatological field 

The present invention relates to novel antiacne compositions containing extract of Krameria, or a pure compound from the extract, at least one of ximeninic acid or lauric acid, and an anti-inflammatory saponin extracted from or mixtures thereof.

Pharmaceutical and cosmetic formulations with antimicrobial activity

The present invention relates to novel antimicrobial or preservative formulations exhibiting enhanced antimicrobial activity containing extract of Krameria, or a pure compound from the extract and extract of,The antimicrobial or preservative formulations are applied to pharmaceutical or cosmetic compositions which may also contain ximeninic acid, lauric acid, an anti-inflammatory saponin extracted from,or mixtures thereof.

The present invention relates to the use of esculoside alone or in combination with adenylate cyclase stimulators, such as forskolin or Salvia miltiorrhiza diterpenes and/or with phosphodiesterase inhibitors, such as apigenine-skeleton dimeric flavones, in topical formulations for the treatment of peripheral vasculopathies related to an impaired peripheral microcirculation, cellulitis or unesthetisms connected with a deposit of superfluous fat. For the reduction of the deposits of superfluous fat of any origin, the above mentioned products are advantageously also combined with caffeine, theophylline and derivatives thereof.

Formulations containing esculoside and the use thereof in the

The present invention relates to novel formulations useful in the preventive and curative treatment of hair loss and of seborrhea, containing coumarins such as khellin, visnadin, esculoside or alkaloids such as raubasine, vincamine and derivatives thereof, combined with unsaturated and saturated fatty acids.

Combinations of vasoactive substances with fatty acids to prevent hair

The present invention relates to the use of coumarins such as esculoside, esculetin, extracts containing them and mixtures thereof, in combination with dimeric and oligomeric proanthocyanidins, in topical formulations for the treatment of peripheral vasculopathies, including the complications of acute venous stasis, or of the unesthetisms related to capillary alterations, or to improve the cicatrization processes. These coumarins, alone or in combination with proanthocyanidins, are also useful in atopical dermatitis and in the treatment of the haematomas.

Formulations containing coumarins and the use thereof in the

Triterpene saponins of formula ##STR1## wherein R.sub.1 is H or OH and R.sub.2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said saponins are isolated from roots and bark of Crossopteryx febrifuga, for instance by precipitating them, in form of a complex with cholesterol or sytosterol, from an alcoholic extract of the vegetal material and by partitioning the precipitate between an apolar solvent, which subtracts the complexing agent and a polar solvent in which saponins are soluble.

Growing community of inventors

Milan, Italy

Aldo Cristoni