Blaschim S.p.a.

Zambon Group

Montedison S.p.a.

Blasinachim S.p.a.

Wyeth

Biaschim S.p.a.

Aldo Belli

Claudio Giordano

Giovanni Villa

Fulvio Uggeri

Marco Villa

Mauro Napoletano

Attilio Citterio

Francesco Ponzini

Pietro Allegrini

Livius Cotarca

Carlo Venturello

Massimo Verzini

Rino D'Aloisio

Maurizio Paiocchi

Francesco Minisci

Giorgio Soriato

Vincenzo Cannata

Giancarlo Grancini

Kadum A Ali

Roberto Brescello

Oreste Piccolo

Enrico Zen

Carl E Longfellow

Biase Continanza

Fabio Rondina

Lucio Filippini

Malama K Chibwe

Laura Tinucci

Shridhar G Gangolli

The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.

Crystalline polymorph of bazedoxifene acetate

A process for the nitration of conjugated alkenes of formula (I) wherein R, R1, R2, R3 and R4 have the meanings reported in the description, which allows to obtain the corresponding &#x3b2;-nitro-alkenes, characterised in that the nitrating agent is a mixture of an inorganic nitrite and iodine in the presence of an oxidising agent is described.

Process for the preparation of nitroalkenes

A compound of formula (II), wherein R,is chloro, fluoro or trifluoromethyl; R,is hydrogen, chloro, fluoro or trifluoromethyl; and R is hydrogen or a protective group for the hydroxy moiety useful as an intermediate for the synthesis of antimycotic azole compounnds.

Diol compounds as intermediates for preparing antimycotic compounds

Process for the preparation of a compound of formula (VII) wherein R,is Cl, F or CF,; R,is H, Cl, F or CF,; and R,is C,alkyl; characterized in that an olefin of formula (II) is epoxidized to give an oxirane of formula (III) which treated with alkyl-magnesium halide gives a triol of formula (IV) which is turned into an epoxide of formula (V), then treated with 1,2,4-triazole. The compounds (VII) are useful for preparing azole derivatives active as antifungal agent.

Process for preparing triazole antimycotic compounds

Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals in the presence of a Lewis acid. The rection is preferably carried out in the presence of catalytic amounts of a Lewis acid and of a diluent at a temperature in the range from about 0.degree. to the reflux temperature of diluent. The esters thus obtained are useful as intermediate products for preparing drugs. The process involves the preparation of new alpha-haloketals.

Process for preparing esters of alkanoic acids via rearrangement of

Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-one in the presence of a Lewis acid. The esters thus obtained are useful as intermediate products for preparing Naproxen. The process involves the preparation of the following new compounds:

Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid

Process for preparing an arylalkanoic acid by adding iodine to a mixture of an arylalkanone and an excess of an orthoester, heating of the mixture thus obtained, adding an inorganic base and finally an acid.

Process for the preparation of arylalkanoic acids by oxidative

Preparation of esters of 2-(6'-methoxy-2'-naphthyl)-propionic acid via

Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.

Process for preparing biaryl compounds via coupling of an arylamine with

Process for preparing esters of 2-(6'methoxy-2'naphtyl)-propionic acid

This invention relates to a process for the preparation of 4-[2-(dimethylamino)-ethoxy]-2-methyl-5-(1-methylethyl)-phenol esters (I) and their salts with organic and inorganic acids comprising the reaction of thymol with a salt of an 1-halo-dimethylaminoethane to obtain ethylamine-N,N-dimethyl-2-(thymyloxy) (II), the subsequent reaction of (II) with an acylating agent according to the Friedel and Kraft reaction to obtain 4-[2-(dimethylamino)-ethoxy]-2-methyl-5-(1-methylethyl)-1-acyl-benzene (III) and the oxidation of (III) to obtain the products (I) which, if desired, may be transformed in their salts with organic or inorganic acids. This process allows to obtain the products (I) in high quality and quantity without isolating any intermediate product.

Process for the preparation of

Alpha-naphthol esters of aliphatic carboxylic acids are prepared by oxidation of naphthalene in the presence of cobalt compounds.

Process for preparing alpha-naphthol esters of aliphatic carboxylic acids

The present invention concerns a process for the preparation of 2-(4'-nitrophenyl)-propionic acid of the formula (I): ##STR1## More particularly, this invention relates to a process for the preparation of 2-(4'-nitrophenyl)-propionic acid (I) starting from para-nitroethylbenzene (PNEB) by carboxylation in the presence of alkaline phenates (Na and K). The 2-(4'-nitrophenyl)-propionic acid (I) thus obtained finds a useful application as an intermediate for the preparation of chemical products. For instance, acid (I) may be hydrogenated catalytically until obtaining the corresponding amino-derivative which is then condensed with ortho-cyanobenzyl-bromides in order to give isoindoline (as described in Belgian Pat. No. 774985).

Process for the preparation of 2-(4'-nitrophenyl)-propionic acid

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