Glaxo S.p.a.

Glaxo Group Limited

Glaxo Wellcome Spa

Alcide Perboni

Tino Rossi

Giovanni Gaviraghi

Daniele Andreotti

Daniele Donati

Claudio Bismara

Giorgio Pentassuglia

Giorgio Tarzia

Bruno Tamburini

Roberto Carlesso

William L Mitchell

Gerard Martin Paul Giblin

Paolo Maragni

Antonella Ursini

Giuseppe Guercio

Stefano Biondi

Andrew John Eatherton

Ilaria Bientinesi

Brian Peter Slingsby

Zadeo Cimarosti

Matthew Russell Johnson

Stuart Holman

John Alexander Winders

Corinne Leroi

Simon Charles Dolan

The present invention relates to a new and useful process for preparing N,N-substituted carbamoyl halides from secondary amines, carbon dioxide, trialkylsilyl chloride and a halogenating agent.

Process for preparing N, N-substituted carbamoyl halides

The present invention relates to novel pyrrolopyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.

Pyrrolopyridine derivatives

A process for the preparation of the phosphonium compound of formula (1), which comprises reacting N-phenylpyrrolidinone (II), with pyridinium bromide perbromide, in the presence of a tertiary organic base and a suitable lewis acid and then treating the resultant bromo derivative (III) with the phosphine (IV, R,R,R,P) and the use of compound (I) when so prepared for the preparation of the glycine antagonist.

Preparation of phosphonium compounds as intermediates for glycine antagonists

Urea derivatives for use in treating bacterial infections

A compound of the formula 1-cyclohexyloxycarbonyloxethyl (4S, 8S, 9R 10S, 12R)-4-methoxy-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0..sup.3,8 ]undec-2-ene-2-carboxylate which is useful as a pharmaceutical composition to treat bacterial infection.

10(1-hydroxyethyl)-11-oxo-1-azatricyclo/7.2.0.0..sup.3.8/

1-azatricyclo[7.2.0.0.sup.3,8 ]undec-2-ene-2-carboxylates as

Tricyclic carbapenem compounds, methods of preparation and methods of use

The invention relates to heterocyclic derivatives having antibacterial activity, to processes for their preparation, to compositions containing them, and to their medicinal uses. The derivatives according to the invention have the following general formula: ##STR1##

Derivatives of 1-azatricyclo[7.2.03,8]undec-2-ene-2-carboxyclic acid

Compounds of formula ##STR1## in which R.sub.1 represents a hydrogen atom or a hydroxyl protecting group; R.sub.2 represents a hydrogen atom or a trialkylsilyl group, and --X--Y-- represents the epoxide group (A) or the alkene group (B). ##STR2## wherein R.sub.3 represents a C.sub.1-6 alkyl group optionally substituted by halogen or an optionally substituted phenyl group, useful as intermediates in the preparation of antibacterially active compound.

4-cyclohexenyl azetidinone derivatives

Compounds of formula ##STR1## in which R.sub.1 is hydrogen or a hydroxyl protecting group and --X--Y-- is --CH.dbd.CH-- or ##STR2## useful as intermediates in the preparation of antibacterially active compounds.

4-cyclohexenyl azetidinones and epoxy derivatives thereof

Compounds of the general formula (I) ##STR1## in which: R.sub.1 represents a hydroxyl protecting group; and

4-(2-Oxo-cyclohexyl) azetidinones

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Verona, Italy

Alcide Perboni