University of South Florida

University of Wyoming

Colorado State University Research Foundation

Alberto Van Olphen

Thomas R Hansen

Kirpal Singh Bisht

Kathleen Jeanette Austin

Pasha M Khan

Natalia P Smirnova

Cynthia Bucher

Lea A Rempel

Ruizhi Wu

Compositions and methods for the detection, diagnosis and treatment of BVDV and other viruses are provided.

Surrogate markers for viral infections and other inflammatory responses

Compositions and methods for the detection, diagnosis and treatment of BVDV are provided.

Markers for viral infections and other inflammatory responses

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (&#x3e;99% ee) was influenced by desymmetrization catalyzed bylipase and the stereo selective nature of the palladium catalyzed transformations.

Antiviral activity of cyclopentene nitro-ester and derivatives

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (&#x3e;99% ee) was influenced by desymmetrization catalyzed bylipase and the stereoselective nature of the palladium catalyzed transformations.

Formation of cyclopentene nitro-ester and derivatives

Growing community of inventors

Tampa, FL, United States of America

Alberto Van Olphen