Italfarmaco Spa

Gruppo Lepetit

Zambon Group

Zambon S.p.a.

Alfa Lancia Industriale S.p.a.

Alberto Sala

Francesca Benedini

Roberta Cereda

Dario Chiarino

Mauro Napoletano

Giorgio Bertolini

Giorgio Winters

Aldo Banfi

Gianni Gromo

Silvio Levi

Angelo Carenzi

Davide Della Bella

Domenico Barone

Gianfranco Pavich

Fabrizio Marcucci

Giuliana Porro

Piero Soldato

Giancarlo Dona

Roberto Barani

Diesters of carbonic acid disubstituted with primary, secondary or tertiary amine groups, pharmaceutically acceptable salts thereof, and their use as antiviral and inti-inflammatory agents.

Diesters of carbonic acid endowed with antiviral and anti-inflammatory

##STR1## Compounds of formula (I) wherein X, Y, R.sub.1 and R.sub.2 have the meanings specified in the specification, are endowed with cardiovascular activity.

Benzoic acid substituted derivatives having cardiovascular activity

Compounds of formula I ##STR1## wherein R represents hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl, methylene-dioxy or phenyl, which may be substituted by one or two groups independently selected from hydroxy, halogen, nitro, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy; R.sub.1 and R.sub.2 independently represent hydrogen, COOR.sub.3, --CONR.sub.4 R.sub.5, ##STR2## --OCONR.sub.4 R.sub.5, --OCOR.sub.3, --NR.sub.4 R.sub.5, --OCOOR.sub.6, --NR.sub.3 COR.sub.7, --NR.sub.CONR.sub.4 R.sub.5, --N.dbd.CH--NR.sub.4 R.sub.5, NO.sub.2, CN, OH, SR.sub.3, wherein R.sub.3 is hydrogen or C.sub.1 -C.sub.6 alkyl, R.sub.4 and R.sub.5 independently are hydrogen or C.sub.1 -C.sub.6 alkyl, R.sub.6 is C.sub.1 -C.sub.6 alkyl, and R.sub.7 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy, with the proviso that R.sub.1 and R.sub.2 cannot be hydrogen at the same time; X is oxygen or sulphur; Y represents a C.sub.2 -C.sub.6 alkylene chain or a C.sub.5 -C.sub.7 cycloalkylene group; and their pharmaceutically acceptable salts are provided and their use in pharmaceutical compositions which may be used in the treatment of cardiovascular diseases.

Benzoxazinone and benzothiazinone derivatives having cardiovascular

Isoindole compounds of the formula (I) ##STR1## wherein R.sub.1 represents hydrogen; C.sub.1 -C.sub.6 alkyl; benzyl optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, methylenedioxy; C.sub.2 -C.sub.8 aliphatic acyl; benzoyl optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.6 alkanoyl, C.sub.2 -C.sub.6 alkanoyloxy, C.sub.1 -C.sub.4 alkyl, trifluoromethyl, methylenedioxy;

Isoindoles having cardiovascular activity

Isoxazoles with nootropic activity

A silencer for the exhaust gas of motor vehicle internal combustion engines is proposed comprising an outer wall having in its upper part a deformable zone, preferably in the form of a transverse indentation, which provides preferential deformation under impact, and if a rear impact occurs prevents the silencer from rigidly striking the most inner structure of the vehicle floor and the fuel tank.

Silencer for the exhaust gas of motor vehicle internal combustion engines

Process for the preparation of 3,5-disubstituted isoxazoles

New isoxazole[5,4-b]pyridines having antiinflammatory, CNS-depressant and cardiovascular activity.

Antiinflammatory and anxiolytic isoxazole-[5,4-b]pyridines

The present invention is directed to new pyrazolo/4,3-c/pyridines, the process for their preparation, the pharmaceutical compositions containing them and their use as pharmocologically active substances. The compounds of the invention possess cardiotonic, antihypertensive, CNS depressant, neuroleptic, and analgesic activity.

Pharmacologically active pyrazolo/4,3-c/pyridines

Growing community of inventors

Milan, Italy

Alberto Sala