Politecnico Di Milano

Sorin Group Italia S.r.l.

Edwards Lifesciences Corporation

The University of Arizona

The State University of New York

Fondazione Istituto Italiano Di Tecnologia

Fondazione Cariplo

Alberto Redaelli

Stefano Reggiani

Gianfranco Beniamino Fiore

Christian Baiotto

Francesco Maisano

Ottavio Alfieri

Claudio Silvestri

Alberto Giri

Alain F Carpentier

Marvin J Slepian

Patrick M McCarthy

Marco Rasponi

Gabriele Tommasi

Danny Bluestein

Stefano Donini

Emilio Parisini

Federica Rigoldi

Alfonso Gautieri

Giuseppe Susini

Monica Soncini

Paola Occhetta

A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.

Blood processing unit with modified flow path

The present invention refers to Amadoriase enzyme protein variants having de-glycating activity and improved thermostability compared to the wild type Amadoriase. The present invention refers also to the use of the thermostabilized Amadoriase as deglycating agent, preferably in the food industry. Moreover, the present invention refers to the use of the thermostabilized Amadoriase as diagnostic and/or therapeutic tools. Preferably, the Amadoriase enzyme protein variants of the invention can be used for determining the level of glycated haemoglobin in a biological sample and therefore for monitoring diabetes.

Thermostabilized Amadoriases and uses thereof

Provided herein are devices, systems, and methods for analyzing platelet function. In particular, provided herein are simple, portable, accurate and inexpensive small footprint platelet aggregometry devices, systems, and methods.

Systems and methods for analyzing platelet function

A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.

Microfluidic devices and related methods for generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs

Provided herein is technology relating to microfluidic devices and particularly, but not exclusively, to devices, methods, systems, and kits for imparting stresses on a fluid flowing through a microfluidic device that is designed to mimic a stress profile of a macrofluidic device or pathology.

Methods, devices, and systems for microfluidic stress emulation

Methods of remodeling an abnormal mitral valve with an annuloplasty ring having a reduced anterior-to-posterior dimension to restore coaptation between the mitral leaflets in mitral valve insufficiency (IMVI). The ring has a generally oval shaped body with a major axis perpendicular to a minor axis. An anterior section lies between anteriolateral and posteriomedial trigones, while a posterior section defines the remaining ring body and is divided into P, P, and Psegments. The anterior-to-posterior dimension of the ring body is reduced from conventional rings; such as by providing, in atrial plan view, a pulled-in Psegment. The ring body may have a downwardly deflected portion in the posterior section. The downwardly deflected portion may have an apex which is the lowest elevation of the ring body and may be offset with respect to the center of the downwardly deflected portion toward the Psegment.

Methods for repairing mitral valves

An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger, an arterial filter, and a filter frame. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some embodiments, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood.

Oxygenator with integrated arterial filter including filter frame

A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to provide a circumferential blood flow through the heat exchanger and/or gas exchanger.

Blood processing unit with circumferential blood flow

A blood processing apparatus includes a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger is configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. In some instances, the heat exchanger is configured to cause blood flow to follow a spiral flow path.

The present invention refers to an annular prosthesis for mitral valve. In one of its embodiments the annular prosthesis for mitral valve is made up of a posterior half-ring and an anterior half-ring coupled to each other on a first transverse plane which defines a maximum width section of the prosthesis, characterized in that the ratio between the distance between said anterior half-ring and said posterior half-ring, as measured along a second plane, perpendicular to said first plane and equidistant to said couplings, and said maximum width of the prosthesis is lower than &#xbe;.

Methods of repairing an abnormal mitral valve

A blood processing apparatus includes a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger is configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. In some instances, a heat exchanger is configured to cause blood flow to follow a spiral flow path.

Growing community of inventors

Milan, Italy

Alberto Redaelli