Universidad De Salamanca

Consejo Superior De Investigaciones Cientificas

Immunostep S.l.

Alberto Orfao De Matos

Ricardo Jara Acevedo

Isidro Sánchez García

Paula Diez Garcia

Manuel Fuentes Garcia

Jesús Perez Losada

Cristina Isabel Gonçalves Grunho Tedosio

Cristina Isabel Gonçalves Grunho Teodosio

The invention relates to methods to evaluate in one single assay the biocompatibility of materials based on the simultaneous determination of the phagocytosis, cell activation and cell death produced by said materials, preferably, in peripheral blood or other human cells and proximal fluids. The invention also relates to a kit to perform the method of the invention.

One step phagocytosis-cell activation-cell death assay

Method for the detection of cancerous cells, in particular, mesenchymal tumoral cells, in a biological sample suspected of containing said malignant cells. The methods are based on the aberrant expression of the Slug gene or transcription or expression products thereof. Also disclosed are methods of treatment that based on the alteration of the transcription or expression of the Slug gene and methods for screening the compounds that have cancer treating activities. Pharmaceutical compositions comprising the anti-cancer compounds are also disclosed.

Use of the slug gene, or of the transcription or expression products thereof in the detection and/or treatment of cancerous cells

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Salamanca, Spain

Alberto Orfao De Matos