Poli Industria Chimica Spa

Euticals Spa

Alberto Mangia

Paride Grisenti

Elisa Verza

Shahrzad Reza Elahi

Riccardo Monti

This invention relates to new water-soluble solid pharmaceutical inclusion complexes and their aqueous solutions for oral, ophthalmic, topical or parenteral use containing a macrolide and certain cyclodextrins. More particularly the invention relates to new water-soluble solid pharmaceutical inclusion complexes and their solutions in aqueous solvents, said compositions containing

Water-soluble solid pharmaceutical inclusion complexes and their aqueous solutions for oral, ophthalmic, topical or parenteral use containing a macrolide and certain cyclodextrins

Process for the preparation of compounds active in the treatment of Parkinson's disease, and such compounds, having general formula (VI) wherein R may be, independently, a linear, branched or cyclic, saturated or unsaturated C alkyl radical, such as, for example, the radicals methyl, ethyl, propyl, butyl, isobutyl, tert-butyl, pentyl, cyclopentyl, hexyl, cyclohexyl and octyl. The process utilizes as starting materials the compound of formula (I) wherein R represents a linear, branched or cyclic, saturated or unsaturated C alkyl residue.

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Basigilio, Italy

Alberto Mangia